Study of the causal relationship between gastroesophageal reflux disease and hypertension through two-sample Mendelian randomization analysis

被引：0

作者：

Li, Weige ^{[1
]}

Wang, Qian ^{[1
]}

Li, Wenjie ^{[1
]}

Liu, Xiang ^{[1
]}

Li, Zuobin ^{[1
]}

Dai, Qi ^{[2
]}

机构：

[1] Jiangxi Univ Chinese Med, Grad Sch, Nanchang, Jiangxi, Peoples R China

[2] Jiangxi Univ Chinese Med, Affiliated Hosp, Dept Gastroenterol, Nanchang, Jiangxi, Peoples R China

来源：

FRONTIERS IN CARDIOVASCULAR MEDICINE | 2024年 / 11卷

关键词：

causal inference; gastroesophageal reflux disease; hypertension; Mendelian randomization; gastroenterology; HIGH BLOOD-PRESSURE; ATRIAL-FIBRILLATION; RISK-FACTOR;

D O I：

10.3389/fcvm.2024.1326348

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective The purpose of this study was to investigate the causal relationship between gastroesophageal reflux disease (GERD) and hypertension using a two-sample Mendelian randomization analysis. Methods The associated data of GERD with hypertension were derived from the genome-wide association study (GWAS) database, and two-sample Mendelian randomization (MR) analysis was performed using methods including inverse variance weighting (IVW), MR-Egger, and weighted median (WM) to investigate the causal association between GERD and hypertension. Results A total of 16 single nucleotide polymorphisms (SNPs) strongly associated with GERD were screened out, and the IVW suggested a causal relationship between GERD and hypertension (OR: 1.057; 95% CI: 1.044-1.071; P < 0.05). The weighted median also showed a similar relationship (OR: 1.051, 95% CI: 1.032-1.07; P < 0.05). In addition, no heterogeneity or horizontal pleiotropy was observed, suggesting a robustness of the outcome. Conclusion There is a positive causal relationship between GERD and hypertension.

引用

页数：7