Neuroimmunometabolism: how metabolism orchestrates immune response in healthy and diseased brain

被引：0
作者：
Rana, Anil Kumar [1 ]
Bhatt, Babita [1 ]
Gusain, Chitralekha [1 ]
Biswal, Surya Narayan [2 ]
Das, Debashree [3 ]
Kumar, Mohit [1 ,4 ]
机构：
[1] Natl Agrifood & Biomfg Inst BRIC NABI, Food & Nutr Biotechnol Div, SAS Nagar, Punjab, India
[2] Cent Univ Punjab, Dept Human Genet & Mol Med, Bathinda, Punjab, India
[3] Brandeis Univ, Dept Biol, Waltham, MA USA
[4] Reg Ctr forBiotechnol BRIC RCB, Faridabad, Haryana, India
来源：
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM | 2025年 / 328卷 / 02期
关键词：
depression; immunometabolism; microglia; neuroinflammation; psychiatric diseases; NECROSIS-FACTOR-ALPHA; BIPOLAR DISORDER; WHITE-MATTER; FATTY-ACIDS; MICROGLIA; INFLAMMATION; DEPRESSION; SPECTRUM; CORTEX; INTERLEUKIN-1-BETA;
D O I：
10.1152/ajpendo.00331.2024
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Neuroimmunometabolism describes how neuroimmune cells, such as microglia, adapt their intracellular metabolic pathways to alter their immune functions in the central nervous system (CNS). Emerging evidence indicates that neurons also orchestrate the microglia-mediated immune response through neuro-immune cross talk, perhaps through metabolic signaling. However, little is known about how the brain's metabolic microenvironment and microglial intracellular metabolism orchestrate the neuroimmune response in healthy and diseased brains. This review addresses the balance of immunometabolic substrates in healthy and diseased brains, their metabolism by brain-resident microglia, and the potential impact of metabolic dysregulation of these substrates on the neuroimmune response and pathophysiology of psychiatric disorders. This review also suggests metabolic reprogramming of microglia as a preventive strategy for the management of neuroinflammation-related brain disorders, including psychiatric diseases.
引用
收藏
页码：E217 / E229
页数：13
相关论文
共 128 条
  • [11] Wang L, Pavlou S, Du X, Bhuckory M, Xu H, Chen M., Glucose transporter 1 critically controls microglial activation through facilitating glycolysis, Mol Neurodegener, 14, (2019)
  • [12] Baik SH, Kang S, Lee W, Choi H, Chung S, Kim JI, Mook-Jung I., A breakdown in metabolic reprogramming causes microglia dysfunction in Alzheimer’s disease, Cell Metab, 30, pp. 493-507, (2019)
  • [13] Li Q, Barres BA., Microglia and macrophages in brain homeostasis and disease, Nat Rev Immunol, 18, pp. 225-242, (2018)
  • [14] Nair S, Sobotka KS, Joshi P, Gressens P, Fleiss B, Thornton C, Mallard C, Hagberg H., Lipopolysaccharide-induced alteration of mitochondrial morphology induces a metabolic shift in microglia modulating the inflammatory response in vitro and in vivo, Glia, 67, pp. 1047-1061, (2019)
  • [15] Cheng J, Zhang R, Xu Z, Ke Y, Sun R, Yang H, Zhang X, Zhen X, Zheng LT., Early glycolytic reprogramming controls microglial inflammatory activation, J Neuroinflammation, 18, (2021)
  • [16] Fodelianaki G, Lansing F, Bhattarai P, Troullinaki M, Zeballos MA, Charalampopoulos I, Gravanis A, Mirtschink P, Chavakis T, Alexaki VI., Nerve growth factor modulates LPS - induced microglial glycolysis and inflammatory responses, Exp Cell Res, 377, pp. 10-16, (2019)
  • [17] Orihuela R, McPherson CA, Harry GJ., Microglial M1/M2 polarization and metabolic states, Br J Pharmacol, 173, pp. 649-665, (2016)
  • [18] Kurematsu C, Sawada M, Ohmuraya M, Tanaka M, Kuboyama K, Ogino T, Matsumoto M, Oishi H, Inada H, Ishido Y, Sakakibara Y, Nguyen HB, Thai TQ, Kohsaka S, Ohno N, Yamada MK, Asai M, Sokabe M, Nabekura J, Asano K, Tanaka M, Sawamoto K., Synaptic pruning of murine adult-born neurons by microglia depends on phosphatidylserine, J Exp Med, 219, (2022)
  • [19] Sariol A, Mackin S, Allred MG, Ma C, Zhou Y, Zhang Q, Zou X, Abrahante JE, Meyerholz DK, Perlman S., Microglia depletion exacerbates demyelination and impairs remyelination in a neurotropic coronavirus infection, Proc Natl Acad Sci USA, 117, pp. 24464-24474, (2020)
  • [20] Michell-Robinson MA, Touil H, Healy LM, Owen DR, Durafourt BA, Bar-Or A, Antel JP, Moore CS., Roles of microglia in brain development, tissue maintenance and repair, Brain, 138, pp. 1138-1159, (2015)
12345678910