Solubility Measurements of Finerenone in Ten Monosolvents and Two Binary Solvent Mixtures

被引:0
|
作者
Lin, Jia [1 ]
Wu, Yanfang [1 ]
Chang, Shengyuan [1 ]
Liu, Yan [1 ]
机构
[1] East China Univ Sci & Technol, Engn Res Ctr Pharmaceut Proc Chem, Sch Pharm, Minist Educ, Shanghai 200237, Peoples R China
来源
JOURNAL OF CHEMICAL AND ENGINEERING DATA | 2025年 / 70卷 / 03期
关键词
SOLUTION THERMODYNAMICS; ORGANIC-SOLVENTS;
D O I
10.1021/acs.jced.5c00011
中图分类号
O414.1 [热力学];
学科分类号
摘要
The solubility of finerenone, a third-generation nonsteroidal mineralocorticoid receptor antagonist drug, was measured in 10 monosolvents (methanol, ethanol, isopropanol, methyl acetate, ethyl acetate, isopropyl acetate, acetone, 2-butanone, acetonitrile, and dichloromethane) and two binary solvent mixtures (methanol + water and acetonitrile + water). Measurements were conducted at temperatures ranging from 273.15 to 313.15 K using PAT tools. In the methanol + water system, water acted solely as an antisolvent. However, in the acetonitrile + water system, finerenone's solubility exceeded its solubility in pure acetonitrile, reaching a maximum at a water mass fraction of approximately 0.2. To expand the applicability of the results, the experimental solubility data was correlated with the modified Apelblat model, the lambda h model, and the CNIBS/R-K model. The relative average deviation and root-mean-square deviation values indicate that the correlation results align well with the experimental data, and the modified Apelblat model proved the most suitable.
引用
收藏
页码:1527 / 1536
页数:10
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