The cGAS-STING pathway and female reproductive system diseases

被引：1

作者：

Li, Ruijie ^{[1
]}

Liu, Hengwei ^{[2
]}

Liu, Yi ^{[1
]}

机构：

[1] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Obstet & Gynecol, Wuhan, Peoples R China

[2] Wuhan Univ, Zhongnan Hosp, Dept Obstet & Gynecol, Wuhan, Peoples R China

来源：

FRONTIERS IN IMMUNOLOGY | 2024年 / 15卷

基金：

中国国家自然科学基金;

关键词：

cGAS-STING; female reproductive system; endometriosis (EM); adenomyosis (AM); ovarian cancer; CYCLIC GMP-AMP; HUMAN-PAPILLOMAVIRUS TYPE-16; HLA CLASS-I; ANTIMALARIAL-DRUGS; DOWN-REGULATION; DI-GMP; DNA; CANCER; ENDOMETRIOSIS; ACTIVATION;

D O I：

10.3389/fimmu.2024.1447719

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The cGAS-STING pathway has become a crucial role in the detection of cytosolic DNA and the initiation of immune responses. The cGAS-STING pathway not only mediates protective immune defense against various DNA-containing pathogens but also detects tumor-derived DNA to generate intrinsic anti-tumor immunity. However, abnormal activation of the cGAS-STING pathway by self-DNA can also lead to autoimmune diseases and inflammatory disorders. This article reviews the mechanisms and functions of the cGAS-STING pathway, as well as the latest research progress in female reproductive-related diseases. We focus on the regulatory mechanisms and roles of this pathway in common female reproductive disorders, discuss the clinical potential of the cGAS-STING pathway as biomarkers and therapeutic agents for female reproductive diseases, as well as the research controversies, technical issues, and biological knowledge gaps that need to be resolved. Furthermore, we provide new ideas for the treatment and prevention of these diseases.

引用

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