Nonvesicular trafficking of cholesterol by Aster proteins

被引：0
|
作者：
Norris, Dougall [1 ]
Aw, Yvette [1 ]
Yang, Hongyuan [1 ]
机构：
[1] Univ New South Wales, Sch Biotechnol & Biomol Sci, Sydney, NSW 2052, Australia
来源：
LIFE METABOLISM | 2023年 / 2卷 / 02期
关键词：
D O I：
10.1093/lifemeta/load003
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
In a recent article published in Nature Metabolism, Peter Tontonoz and colleagues found that the Aster/GramD1 proteins were required for plasma membrane (PM) cholesterol to reach the endoplasmic reticulum (ER) in mouse liver during fasting, low-density lipoprotein (LDL) uptake, or reverse cholesterol transport (RCT). The Aster/GramD1 pathway plays a key role in maintaining hepatic and systemic cholesterol/lipid homeostasis. © 2022 The Author(s).
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页数：2
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