Autism, youth suicide, and psychedelics: A review of the 21st century evidence

被引：3

作者：

Chen, Mu-Hong ^{[1
,2
]}

Su, Tung-Ping ^{[1
,2
,3
]}

Hsu, Ju-Wei ^{[1
,2
]}

Tsai, Shih-Jen ^{[1
,2
]}

机构：

[1] Taipei Vet Gen Hosp, Dept Psychiat, 201,Sect 2,Shi Pai Rd, Taipei 112, Taiwan

[2] Natl Yang Ming Chiao Tung Univ, Fac Med, Div Psychiat, Taipei, Taiwan

[3] Gen Cheng Hsin Hosp, Dept Psychiat, Taipei, Taiwan

来源：

JOURNAL OF THE CHINESE MEDICAL ASSOCIATION | 2024年 / 87卷 / 10期

关键词：

21st century; Autism; Psychedelics; Youth suicide; SPECTRUM DISORDER; ASPERGERS-SYNDROME; SEROTONIN; ADULTS; DEPRESSION; PSILOCYBIN; CHILDREN; ASSOCIATION; ADOLESCENTS; PREVALENCE;

D O I：

10.1097/JCMA.0000000000001150

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The concurrent rise in the prevalence of autism and youth suicide has drawn public health and professional attention. The renaissance of psychedelics in psychiatry occurred in the early 21st century and may suggest a hope for the therapeutic effect of psychedelics in autism and suicide. The psychedelics' molecular entities are the compounds that modulate the serotoninergic and glutamatergic systems, which play a crucial role in the pathomechanisms underlying autism and suicide. This systematic review comprehensively discussed the prevalence trends of autism and youth suicide globally and in Taiwan and discussed an association between autism and suicidality based on the 21st century clinical and preclinical literature. Furthermore, this review proposed a possible neurobiological connection between autism, suicide, and psychedelics. Finally, this review discussed the potential therapeutic applications of psychedelics in autism and youth suicide.

引用

页码：904 / 911

页数：8

共 97 条

[1]

Anisman H, 2008, J PSYCHIATR NEUROSCI, V33, P131

[2] Classical hallucinogens as antidepressants? A review of pharmacodynamics and putative clinical roles [J].

Baumeister, David ;

Barnes, Georgina ;

Giaroli, Giovanni ;

Tracy, Derek .

THERAPEUTIC ADVANCES IN PSYCHOPHARMACOLOGY, 2014, 4 (04) :156-169

[3] MDMA-assisted psychotherapy for post-traumatic stress disorder: The devil is in the detail [J].

Bedi, Gillinder ;

Cotton, Susan M. ;

Guerin, Alexandre A. ;

Jackson, Henry J. .

AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY, 2023, 57 (04) :476-481

[4]

BENDER L, 1961, Recent Adv Biol Psychiatry, V4, P170

[5] The prescription of psychedelic therapies in Australia and New Zealand: A brief survey of psychiatrists [J].

Berger, Joshua J. ;

Fitzgerald, Paul B. .

AUSTRALASIAN PSYCHIATRY, 2023, 31 (02) :190-194

[6] Global trends in youth suicide from 1990 to 2020: an analysis of data from the WHO mortality database [J].

Bertuccio, Paola ;

Amerio, Andrea ;

Grande, Enrico ;

La Vecchia, Carlo ;

Costanza, Alessandra ;

Aguglia, Andrea ;

Berardelli, Isabella ;

Sera, Gianluca ;

Amore, Mario ;

Pompili, Maurizio ;

Odone, Anna .

ECLINICALMEDICINE, 2024, 70

[7] Ketamine as a Prophylactic Against Stress-Induced Depressive-like Behavior [J].

Brachman, Rebecca A. ;

McGowan, Josephine C. ;

Perusini, Jennifer N. ;

Lim, Sean C. ;

Thu Ha Pham ;

Faye, Charlene ;

Gardier, Alain M. ;

Mendez-David, Indira ;

David, Denis J. ;

Hen, Rene ;

Denny, Christine A. .

BIOLOGICAL PSYCHIATRY, 2016, 79 (09) :776-786

[8]

CAMPBELL M, 1975, BIOL PSYCHIAT, V10, P399

[9]

Canal CE, 2018, HANDB EXP PHARMACOL, V252, P227, DOI 10.1007/164_2018_107

[10] Psilocybin with psychological support for treatment-resistant depression: six-month follow-up [J].

Carhart-Harris, R. L. ;

Bolstridge, M. ;

Day, C. M. J. ;

Rucker, J. ;

Watts, R. ;

Erritzoe, D. E. ;

Kaelen, M. ;

Giribaldi, B. ;

Bloomfield, M. ;

Pilling, S. ;

Rickard, J. A. ;

Forbes, B. ;

Feilding, A. ;

Taylor, D. ;

Curran, H. V. ;

Nutt, D. J. .

PSYCHOPHARMACOLOGY, 2018, 235 (02) :399-408

← 1 2 3 4 5 6 7 8 9 10 →