New flavonoid glycosides from the stems and leaves of Astragalus membranaceus

Astragalus membranaceus, a well-known traditional medicine and food, has been extensively studied for its roots. However, comparatively little attention has been paid to its stems and leaves. In this study, we successfully isolated and identified three new flavonoid glycosides (1-3), and eight known analogues ( 4-11 ) from the stems and leaves of A. membranaceus. Notably, compound 10 exhibited significant anti-inflammatory activities in LPSinduced BV2 cells, with IC50 value of 1.11 +/- 0.04 mu M . These findings highlight flavonoids as the key bioactive components present in the stems and leaves of A. membranaceus.