Prognostic significance of electrophysiological study in drug-induced type-1 Brugada syndrome: a brief systematic review

被引:2
|
作者
Mascia, Giuseppe [1 ]
Brugada, Josep [2 ,3 ,4 ,5 ,6 ]
Barca, Luca [7 ]
Benenati, Stefano [7 ]
Della Bona, Roberta [1 ]
Scara, Antonio [8 ]
Russo, Vincenzo [9 ]
Arbelo, Elena [3 ,4 ,5 ,6 ]
Di Donna, Paolo [1 ]
Porto, Italo [1 ,7 ]
机构
[1] IRCCS, Osped Policlin San Martino, Cardiovasc Dis Unit, Genoa, Italy
[2] Hosp St Joan de Deu, Inherited Cardiac Dis & Sudden Death Unit, Arrhythmia, Esplugas De Llobregat, Spain
[3] Univ Barcelona, Hosp Clin, Cardiol Dept, Arrhythmia Sect, Barcelona, Spain
[4] Inst Invest August Pi & Sunyer IDIBAPS, IDIBAPS, Barcelona, Spain
[5] Ctr Invest Biomed Red Enfermedades Cardiovasc CIBE, Madrid, Spain
[6] European Reference Network Rare Low Prevalence & C, Amsterdam, Netherlands
[7] Univ Genoa, Dept Internal Med, Genoa, Italy
[8] San Carlo Nancy Hosp, Dept Cardiol, Rome, Italy
[9] Univ Campania, Monaldi Hosp, Dept Med Translat Sci, Cardiol Unit, Naples, Italy
关键词
Brugada syndrome; electrophysiological study; risk assessment; sudden cardiac death; PROGRAMMED VENTRICULAR STIMULATION; PREVIOUS CARDIAC-ARREST; LONG-TERM PROGNOSIS; ELECTROCARDIOGRAPHIC PATTERN; RISK STRATIFICATION; DEATH;
D O I
10.2459/JCM.0000000000001665
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
BackgroundRisk stratification in drug-induced type-1 Brugada syndrome (BrS) patients is challenging. The role of electrophysiological study (EPS) is debated as the majority of drug-induced type-1 BrS patients would not be studied according to the latest recommendations.MethodsA complete systematic literature search was performed to gauge the EPS role in this population. Three subgroups were defined: positive-EPS group, negative-EPS group, no-EPS group.ResultsAmong 1318 drug-induced type-1 BrS patients, no significant difference in the incidence rate of arrhythmic events was observed between groups (I2 = 45%, P for subgroup difference = 0.10) during a mean follow-up of 5.1 years, also considering symptomatic status.ConclusionIn long-term follow-up of drug-induced type-1 BrS patients, EPS does not seem to aid prognostic stratification.
引用
收藏
页码:775 / 780
页数:6
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