[1] Univ Toronto, Div Cardiovasc Surg, Toronto, ON, Canada
[2] Univ Toronto, Dept Pharmacol & Toxicol, Toronto, ON, Canada
[3] Univ Hlth Network, Peter Munk Cardiac Ctr, Toronto, ON, Canada
[4] St Michaels Hosp Unity Hlth Toronto, Div Cardiac Surg, 8th Floor,Bond Wing,30 Bond St, Toronto, ON M5B 1W8, Canada