Enhanced stability of curcumin and polyethylene glycol composites in the presence of flavonoids and whey protein concentrate: synthesis, structural evaluation and thermal analysis

被引：0

作者：

Tomoaia-Cotisel, Maria ^{[1
,2
]}

Kun, Attila-Zsolt ^{[1
]}

Racz, Csaba-Pal ^{[1
]}

Tomoaia, Gheorghe ^{[2
,3
]}

Mocanu, Aurora ^{[1
]}

Forizs, Edit ^{[1
]}

Avram, Alexandra ^{[1
]}

Racz, Levente-Zsolt ^{[1
]}

Pop, Lucian-Cristian ^{[1
]}

Sarkozi, Melinda ^{[4
]}

Varhelyi, Csaba, Jr. ^{[1
]}

机构：

[1] Babes Bolyai Univ, Fac Chem & Chem Engn, Res Ctr Excellence Phys Chem, 11 Arany J St, Cluj Napoca 400028, Romania

[2] Acad Romanian Scientists, 3 Ilfov St, Bucharest 050044, Romania

[3] Iuliu Hatieganu Univ Med & Pharm, Dept Orthoped & Traumatol, 47 Gen Traian Mosoiu St, Cluj Napoca 400132, Romania

[4] SC Parapharm SRL, 9 Dacilor St, Brad 335200, Romania

来源：

JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY | 2025年

关键词：

Curcumin; PEG; Whey protein concentrate; Flavonoids; FTIR; Thermal stability; SOLID DISPERSION SYSTEM; BETA-LACTOGLOBULIN; LIPOIC ACID; SOLUBILITY; COMPLEX; ISOLATE; FABRICATION; BINDING; POWDER; NANOCOMPLEXATION;

D O I：

10.1007/s10973-025-14111-0

中图分类号：

O414.1 [热力学];

学科分类号：

摘要：

Curcumin (CCM) is a natural polyphenol with promising pharmacological potential. This potential is severely restricted, however, due to its limited bioavailability, poor solubility and stability. To address this, several systems of curcumin and polyethylene glycol, PEG (PEG4000 or PEG6000), were synthetized, with or without whey protein concentrate (WPC), trans-resveratrol (RES) or silymarin (SIL) using solid dispersion technique. Firstly, CCM-PEG composites were synthesized using PEG4000 or PEG6000 for 1:8 mol ratio by polymer melting method. Further, the CCM-WPC-PEG4000 composite for 1:0.4:8 mol ratio and CCM-WPC-PEG6000 composite for 1:0.5:10 mol ratio were synthesized. Furthermore, CCM-RES-WPC-PEG and CCM-SIL-WPC-PEG composites were prepared for 1:2.5:0.4:10 mol ratio for PEG4000 or PEG6000. The composite formation was investigated by Fourier transform infrared spectroscopy (FTIR). The thermal stability of synthesized composites was analyzed through thermal gravimetric analysis (TGA) and differential scanning calorimetry (DSC) revealing a high stability up to 200 degrees C. Thus, each composite formulation was optimized to carry CCM, RES and WPC or CCM, SIL and WPC within PEG matrix primarily by hydrogen bonds and van der Waals interactions. This study demonstrated that all synthesized composites may have potential advantages for applications such as nutraceuticals, functional foods, supplements and pharmaceuticals.

引用

页数：13

共 75 条

[1]

Racz L.Z., Racz C.-P., Pop L.C., Tomoaia G., Mocanu A., Barbu I., Sarkozi M., Roman I., Avram A., Tomoaia-Cotisel M., Toma V.A., Strategies for improving bioactivity and physical-chemical behavior of the curcumin, Molecules, 27, 20, (2022)

[2]

Racz L., Tomoaia-Cotisel M., Racz C.-P., Bulieris P., Grosu I., Porav S., Ciorita A., Filip X., Martin F., Serban G., Kacso I., Curcumin-whey protein solid dispersion system with improved solubility and cancer cell inhibitory effect, Stud Univ Babeș-Bolyai Chem, 66, 3, pp. 209-224, (2021)

[3]

Racz C.-P., Racz L.Z., Floare C.G., Tomoaia G., Horovitz O., Riga S., Kacso I., Borodi G., Sarkozi M., Mocanu A., Roman C., Tomoaia-Cotisel M., Curcumin and whey protein concentrate binding: thermodynamic and structural approach, Food Hydrocoll, 139, (2023)

[4]

Racz L.Z., Paltinean G.A., Petean I., Tomoaia G., Pop L.C., Arghir G., Levei E., Mocanu A., Racz C.-P., Tomoaia-Cotisel M., Curcumin and whey protein binding and structural characteristics of their complex evidenced by atomic force microscopy, Stud Univ Babeș-Bolyai Chem, 67, 3, pp. 61-74, (2022)

[5]

Nguyen T.T.H., Si J., Kang C., Chung B., Chung D., Facile preparation of water soluble curcuminoids extracted from turmeric (Curcuma longa L.) powder by using steviol glucosides, Food Chem, 214, pp. 366-373, (2017)

[6]

Amalraj A., Pius A., Gopi S., Gopi S., Biological activities of curcuminoids, other biomolecules from turmeric and their derivatives—a review, J Tradit Complement Med, 7, pp. 205-233, (2017)

[7]

Li M., Ma J., Cui J., Whey-protein-stabilized nanoemulsions as a potential delivery system for water-insoluble curcumin, LWT Food Sci Technol, 59, pp. 49-58, (2014)

[8]

Racz C.-P., Borodi G., Pop M.M., Kacso I., Santa S., Tomoaia-Cotisel M., Structure of the inclusion complex of β-cyclodextrin with lipoic acid from laboratory powder diffraction data, Acta Crystallogr B, B68, pp. 164-170, (2012)

[9]

Racz C.-P., Santa S., Tomoaia-Cotisel M., Borodi G., Kacso I., Pirnau A., Bratu I., Inclusion of α-lipoic acid in β-cyclodextrin. Physical-chemical and structural characterization, J Incls Phenom Macrocycl Chem, 76, 1, pp. 193-199, (2013)

[10]

Hoang-Thi T.T., Pilkington E.H., Nguyen D.H., Lee J.S., Park K.D., Truong N.P., The Importance of Poly(ethylene glycol) alternatives for overcoming PEG immunogenicity in drug delivery and bioconjugation, Polymers (Basel), 12, 2, (2020)

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