Excessive sleep is associated with worse cognition, cognitive decline, and dementia in mild cognitive impairment

被引：0
作者：
Overton, Marieclaire [1 ]
Sindi, Shireen [2 ,3 ,4 ]
Basna, Rani [1 ]
Elmstahl, Soelve [1 ]
机构：
[1] Lund Univ, Skane Univ Hosp, Dept Clin Sci Malmo, Div Geriatr Med, Jan Waldenstroms Gata35,CRC,Bldg 28,Fl.13, S-20502 Malmo, Sweden
[2] Karolinska Inst, Ctr Alzheimer Res, Div Clin Geriatr, Malmo, Sweden
[3] Karolinska Univ Hosp, Malmo, Sweden
[4] Imperial Coll London, Sch Publ Hlth, Ageing Epidemiol AGE Res Unit, London, England
来源：
ALZHEIMER'S & DEMENTIA: DIAGNOSIS, ASSESSMENT & DISEASE MONITORING | 2025年 / 17卷 / 01期
基金：
瑞典研究理事会;
关键词：
dementia; excessive napping; excessive sleep; long nighttime sleep; mild cognitive impairment; sleep duration; SELF-REPORTED SLEEP; OLDER-ADULTS; ALZHEIMERS-DISEASE; DURATION; DISTURBANCE; SPEED; RISK;
D O I：
10.1002/dad2.70093
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
INTRODUCTIONThis study examines the link between daytime and nighttime excessive sleep and cognition, cognitive decline, and dementia in individuals with existing mild cognitive impairment (MCI).METHODSUsing data from the Swedish longitudinal study Good Aging in Sk & aring;ne, participants aged 60-102 years were retrospectively classified as MCI based on cognitive testing. The average follow-up time was 6.59 years. Mixed linear models assessed cross-sectional and longitudinal associations between excessive sleep patterns (napping >= 2 h or nighttime sleep >= 9 h) and multiple cognitive domains. Cox regressions estimated dementia risk for excessive sleep.RESULTSOf 4930 participants, 2052 (41%) had MCI. Excessive daytime napping and nighttime sleep were associated with worse cognition and cognitive decline. Excessive napping and nighttime sleep were also linked to higher dementia risk (hazard ratios: 1.75 and 1.86, respectively).DISCUSSIONThese findings suggest that excessive sleep in MCI is associated with further cognitive decline and dementia.Highlights Excessive daytime napping and nighttime sleep are linked cognitive decline for those with MCI. Excessive sleep during the day or at night heighten dementia risk. Worse test scores across multiple cognitive domains were observed for excessive daytime nappers. Excessive sleep in MCI may be a warning sign for further cognitive decline.
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页数：13
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