Linezolid-Resistant Coagulase-Negative Staphylococci in a Tertiary Hospital: Molecular Epidemiology, Clinical Characteristics, and Outcomes

被引：0

作者：

Rachina, Svetlana ^{[1
]}

Gostev, Vladimir ^{[2
,3
]}

Pleshkov, Vyacheslav ^{[2
,4
]}

Karpova, Olga ^{[1
]}

Topolyanskaya, Svetlana ^{[1
]}

Melkonyan, Georgy ^{[5
,6
]}

Gladkikh, Marina ^{[5
]}

Zainalabidova, Khadizhat ^{[1
]}

Chulkova, Polina ^{[2
,3
]}

Sidorenko, Sergey ^{[2
,3
]}

机构：

[1] IM Sechenov First Moscow State Med Univ, Moscow, Russia

[2] Pediat Res & Clin Ctr Infect Dis, St Petersburg, Russia

[3] North Western State Med Univ, St Petersburg, Russia

[4] St Petersburg II Dzhanelidze Res Inst Emergency Me, St Petersburg, Russia

[5] War Vet Hosp 3, Moscow, Russia

[6] Russian Med Acad Continuous Profess Educ, Moscow, Russia

来源：

INFECTION AND CHEMOTHERAPY | 2025年 / 57卷 / 01期

关键词：

Linezolid; Tedizolid; Resistance; Staphylococcus epidermidis; ST5; Bacteremia;

D O I：

10.3947/ic.2024.0111

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

We report linezolid-resistant coagulase-negative Staphylococcus (LRCoNS) bacteremia at a tertiary hospital. LRCoNS with linezolid and tedizolid minimum inhibitory concentrations of >32 and 4-32 mg/L, respectively, were isolated from blood cultures of seven elderly patients who died post-bacteremia detection. Linezolid was administered to six of these patients at the time of LRCoNS isolation. Linezolid-resistant S. epidermidis ST5 isolates (LRSE) harboring mecA were isolated in seven of the nine episodes. Linezolid resistance is associated with mutations in the 23S rRNA, L3 and L4 ribosomal proteins, indigenous methyltransferases RlmN, and the presence of the cfr gene. All LRSE-ST5 genomes formed a single phylogenetic cluster.

引用

页码：161 / 167

页数：7

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