Rhodium(III)-Catalyzed Regioselective C4 Alkylation of Indoles with Nitroalkenes

被引：0

作者：

Zhao, Ru ^{[1
]}

Lv, Xulin ^{[1
]}

Yang, Hao-Ran ^{[1
]}

Gao, Lijun ^{[1
]}

Zhou, Liming ^{[1
]}

Fang, Shaoming ^{[1
,2
]}

Liu, Shuang-Liang ^{[1
]}

机构：

[1] Zhengzhou Univ Light Ind, Coll Mat & Chem Engn, Zhengzhou 450001, Peoples R China

[2] Zhengzhou Univ Light Ind, Key Lab Surface & Interface Sci & Technol Henan Pr, Zhengzhou 450001, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2024年 / 89卷 / 23期

基金：

中国国家自然科学基金;

关键词：

DIRECTING-GROUP; H ACTIVATION; FUNCTIONALIZATION; MALEIMIDES; ARYLATION;

D O I：

10.1021/acs.joc.4c02236

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The Rh(III)-catalyzed indole C4-H bond addition to nitroalkenes is disclosed under mild and redox-neutral reaction conditions, offering straightforward access to various 4-(2-nitroalkyl)indoles (34 examples) with excellent chemo- and regioselectivity. Furthermore, late-stage diversifications and mechanistic studies were also performed.

引用

页码：17844 / 17849

页数：6

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