Magnetic Nanoparticles for Targeted Drug Delivery in a Mouse Model of Breast Cancer

被引：0

作者：

Faisal, Faisal ^{[1
]}

Tatarinova, Galiya ^{[2
]}

Ugli, Tursunov Doniyor Mukhamadjon ^{[3
]}

Abdugabbarovna, Djurayeva Lola ^{[4
]}

Ikhtiyorovna, Kamalova Dilnavoz ^{[5
]}

Normuminovna, Kadirova Dilbar ^{[4
]}

Boynazarovich, Mustafoqulov Ruzikul ^{[4
]}

Sapaev, I. B. ^{[6
,7
,8
]}

Rasulovna, Rakhmatova Markhabo ^{[9
]}

Ugli, Khayitov Jamshid Komil ^{[10
]}

Aliyorovna, Gulrukhsor Jumaeva ^{[11
]}

Xamidovna, Mamatkulova Dilrabo ^{[12
]}

Risaliyevich, Isarov Oman Isarov ^{[13
]}

机构：

[1] Univ Islam Malang, Dept Biol, Malang, Indonesia

[2] Kazakh Russian Med Univ, Dept Oncol & Mammol, Alma Ata 050000, Kazakhstan

[3] Andijan State Med Inst, Dept Oncol, Andijan, Uzbekistan

[4] Termez State Univ, Termez, Uzbekistan

[5] Navoi State Pedag Inst, Dept Phys, Navoi, Uzbekistan

[6] Natl Res Univ, Tashkent Inst Irrigat & Agr Mechanizat Engineers, Tashkent, Uzbekistan

[7] Univ Tashkent Appl Sci, Tashkent, Uzbekistan

[8] Western Caspian Univ, Baku, Azerbaijan

[9] Bukhara State Med Univ, Dept Clin Pharmacol, Bukhara, Uzbekistan

[10] Urganch State Univ, Dept Fruits & Vegetables, Urgench, Uzbekistan

[11] Tashkent Med Acad, Dept Rehabil Folk Med & Phys Educ, Tashkent, Uzbekistan

[12] Samarkand State Med Univ, Dept Pediat & Med Genet, Samarkand, Uzbekistan

[13] Natl Res Univ, Tashkent Inst Irrigat & Agr Mechanizat Engineers, Tashkent, Uzbekistan

来源：

JOURNAL OF NANOSTRUCTURES | 2024年 / 14卷 / 01期

关键词：

Breast Cancer; Mouse Model; Tumor Growth; IRON-OXIDE NANOPARTICLES;

D O I：

10.22052/JNS.2024.01.010

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Targeted drug delivery using magnetic nanoparticles (MNPs) has emerged as a promising approach for cancer therapy. This study investigates the efficacy of MNPs for targeted delivery of doxorubicin (DOX) in a mouse model of breast cancer. MNPs were synthesized by co-precipitation and functionalized with DOX. The MNP-DOX conjugates were characterized using TEM, XRD, and FTIR. Female BALB/c mice (n=24) were inoculated with 4T1 breast cancer cells. The mice were divided into four groups: control, DOX, MNP, and MNP-DOX. Every 3 days over a 2-week period, intravenous administration of treatments occurred. Monitoring of tumor volume and body weight took place. Histological analysis and immunohistochemical staining for Ki-67 and caspase-3 were performed on tumor tissues. MNP-DOX conjugates were successfully synthesized and characterized, showing effective drug loading and release. Tumor growth was significantly inhibited in the MNP-DOX group compared to the control, DOX, and MNP groups. The MNP-DOX group exhibited the smallest tumor volume (135 +/- 28 mm3) at the end of the treatment period. Histological analysis revealed increased necrosis and apoptosis in the MNP-DOX group. Immunohistochemical staining showed reduced Ki-67 expression and increased caspase-3 expression in the MNP-DOX group. MNPs functionalized with DOX demonstrated effective targeted drug delivery and enhanced therapeutic efficacy in a mouse model of breast cancer. The MNP-DOX conjugates significantly inhibited tumor growth, increased necrosis and apoptosis, and modulated Ki-67 and caspase-3 expression. These findings support the potential of MNPs as a promising platform for targeted cancer therapy. Further studies are needed to optimize the MNP formulation and assess its safety and efficacy in clinical settings.

引用

页码：101 / 108

页数：8

共 25 条

[1] Iron Oxide@Mesoporous Silica Core-Shell Nanoparticles as Multimodal Platforms for Magnetic Resonance Imaging, Magnetic Hyperthermia, Near-Infrared Light Photothermia, and Drug Delivery [J].