Synthesis of Thiohydantoin Scaffolds on DNA for Focused DNA-Encoded Library Construction

被引：1

作者：

Fang, Xianfu ^{[1
,2
]}

Ju, Yunzhu ^{[1
]}

Wang, Jiayou ^{[1
]}

Zhang, Gong ^{[1
]}

Li, Yangfeng ^{[1
]}

Li, Yizhou ^{[1
]}

机构：

[1] Chongqing Univ, Innovat Drug Res Ctr, Sch Pharmaceut Sci, Chongqing Key Lab Nat Prod Synth & Drug Res, Chongqing 401331, Peoples R China

[2] Chongqing Univ, Pharmaceut Dept, Gorges Hosp 3, Chongqing 404100, Peoples R China

来源：

ORGANIC LETTERS | 2024年 / 26卷 / 41期

基金：

中国国家自然科学基金;

关键词：

DISCOVERY; DRUGS;

D O I：

10.1021/acs.orglett.4c03369

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Thiohydantoin represents a significant class of biologically active privileged heterocyclic scaffolds. Herein, we present a convenient and robust DNA-compatible method for constructing a thiohydantoin-focused DNA-encoded library. This reaction can be applied to a wide variety of isothiocyanate partners, arylamine feedstocks, and diverse alpha-amine acid derivatives, exhibiting excellent conversions, high functional group tolerance, and preservation of DNA tag integrity. Our method allows for easy access to a valuable three-cycle thiohydantoin-focused DNA-encoded library.

引用

页码：8916 / 8921

页数：6

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