Quality of Life Outcomes in Breast Cancer Patients Receiving Chemotherapy With or Without Radiation Therapy

被引：1

作者：

Morse, Ryan T. ^{[1
,3
]}

Bean, Nathan W. ^{[4
]}

Hall, Jacob ^{[1
,3
]}

Deal, Allison ^{[3
]}

Nyrop, Kirsten A. ^{[2
,3
]}

Abdou, Yara ^{[2
,3
]}

Dees, Elizabeth C. ^{[2
,3
]}

Ray, Emily M. ^{[2
,3
]}

Jolly, Trevor A. ^{[2
,3
]}

Reeder-Hayes, Katherine E. ^{[2
,3
]}

Jones, Ellen ^{[1
,3
]}

Gupta, Gaorav P. ^{[1
,3
]}

Elmore, Shekinah ^{[1
,3
]}

Muss, Hyman B. ^{[2
,3
]}

Casey, Dana L. ^{[1
,3
]}

机构：

[1] Univ North Carolina, Dept Radiat Oncol, 101 Manning Dr, Chapel Hill, NC 27514 USA

[2] Univ North Carolina, Dept Med, Div Oncol, Chapel Hill, NC USA

[3] Univ North Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC USA

[4] Univ North Carolina, Gillings Sch Global Publ Hlth, Dept Biostat, Chapel Hill, NC USA

来源：

CLINICAL BREAST CANCER | 2025年 / 25卷 / 01期

关键词：

Patient reported outcomes; Well-being; Fatigue; Radiation side effects; Informed decision-making; REPORTED OUTCOMES; CLINICAL-PRACTICE; RANDOMIZED-TRIAL; FOLLOW-UP; RADIOTHERAPY; METAANALYSIS; IRRADIATION; FATIGUE; WOMEN; OLDER;

D O I：

10.1016/j.clbc.2024.08.015

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Our study compared quality of life (QOL) in women with localized breast cancer receiving chemotherapy with or without radiation therapy. Patient-reported QOL from baseline to post-treatment was noninferior between patients receiving radiation therapy versus those who did not receive radiation therapy. QOL differences in breast cancer patients receiving multimodality therapy helps to understand the impact to patients. Purpose: Understanding quality of life (QOL) implications of individual components of breast cancer treatment is important as systemic therapies continue to improve oncologic outcomes. We hypothesized that adjuvant radiation therapy does not significantly impact QOL domains in breast cancer patients undergoing chemotherapy. Methods: Data was drawn from three prospective studies in women with localized breast cancer being treated with chemotherapy from March 2014 to December 2019. Patient-reported measures were collected at baseline (pretreatment) and post-treatment using the Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F) measure, which consists of 5 subscales. Changes in mean QOL scores in patients who received radiotherapy were compared to those who did not using a onesided noninferiority method. Statistical significance was determined below 0.05 to meet noninferiority. Results: In a sample of 175 patients, 131 were treated with radiation and 44 had no radiation. The sample consisted mostly of stage I-II breast cancer (78%) with hormone receptor positive (59%) disease, receiving either neoadjuvant (36%) or adjuvant chemotherapy (64%). Mean change in QOL for the group treated with radiation compared to no radiation was noninferior with respect to Physical Well-Being ( P = .0027), Social/Family Well-Being ( P = .0002), Emotional Well-Being ( P = .0203), FACIT-Fatigue Subscale ( P = .0072), and the Total FACIT-F score ( P = .0005); however, mean change in QOL did not meet noninferiority for Functional Well-Being ( P = .0594). Conclusion: Patient-reported QOL from baseline to post-treatment, using the Total FACIT-F score, was noninferior in patients treated with versus without radiation therapy. This finding, in addition to individualized QOL subscales, provides important information in the informed decision-making process when discussing the effects of locoregional radiation on QOL in localized breast cancer patients treated with chemotherapy.

引用

页码：e86 / e93

页数：8

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