A Logic-Based Physical Simulation Framework for Digital Microfluidic Biochips

被引:0
|
作者
Madsen, Joel August Vest [1 ]
Jackson, Carl Alexander [1 ]
Collignon, Alexander Marc [1 ]
Madsen, Jan [1 ]
Pezzarossa, Luca [1 ]
机构
[1] Tech Univ Denmark, Dept Appl Math & Comp Sci, Lyngby, Denmark
来源
EMBEDDED COMPUTER SYSTEMS: ARCHITECTURES, MODELING, AND SIMULATION, SAMOS 2024, PT II | 2025年 / 15227卷
关键词
Digital microfluidics biochips; Simulation framework; Logic-based simulation; Web application;
D O I
10.1007/978-3-031-78380-7_1
中图分类号
TP3 [计算技术、计算机技术];
学科分类号
0812 ;
摘要
Digital microfluidic biochips provide a controlled and miniaturized environment to carry out biochemical protocols in an automated fashion. Software-based simulators are essential tools that aid the design of such protocols by enabling users to verify correct execution before targeting the physical biochip. To produce a simulation that is faithful to reality, the fluidic behavior of the droplets and their interaction with the driving electrodes must be taken into account. This paper presents a framework for simulating DMF biochips in a resource-constrained web-based environment. The framework is based on a novel droplet model that uses logic-based calculations to capture fluidic behavior. Thus, enabling to faithfully simulate the movement, merging, and splitting of arbitrary-shaped droplets with a low-computational footprint. The simulation framework also includes modular component models to capture the behavior of sensors and actuators, an event-driven simulation engine, and a graphical user interface. The framework is implemented as a client-side web application and runs in a browser. The evaluation carried out using artificial and real-life test cases shows that the framework can deliver real-time simulations with a high level of fidelity.
引用
收藏
页码:1 / 16
页数:16
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