The interplay between chromatin remodeling and DNA double-strand break repair: Implications for cancer biology and therapeutics

被引：1

作者：

He, Liujun ^{[1
]}

Moon, Jaeyoung ^{[2
]}

Cai, Chenghui ^{[1
]}

Hao, Yalan ^{[3
]}

Lee, Hyorin ^{[2
]}

Kim, Wootae ^{[2
]}

Zhao, Fei ^{[1
]}

Lou, Zhenkun ^{[4
]}

机构：

[1] Hunan Univ, Coll Biol, Changsha 410082, Peoples R China

[2] Soonchunhyang Univ, Soonchunhyang Inst Med Bio Sci SIMS, Dept Integrated Biomed Sci, Cheonan 31151, Chungcheongnam, South Korea

[3] Hunan Univ, Analyt Instrumentat Ctr, Changsha 410082, Peoples R China

[4] Mayo Clin, Dept Mol Pharmacol & Expt Therapeut, Rochester, MN 55905 USA

来源：

DNA REPAIR | 2025年 / 146卷

基金：

新加坡国家研究基金会; 中国国家自然科学基金;

关键词：

Double-strand break; DNA damage; Chromatin remodeling; Cancer; DAMAGE RESPONSE; HOMOLOGOUS RECOMBINATION; SYNTHETIC LETHALITY; COMPLEX-FORMATION; HISTONE H2AX; PROTEIN; LIGASE; XRCC4; XLF; POLY(ADP-RIBOSYL)ATION;

D O I：

10.1016/j.dnarep.2025.103811

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Proper chromatin remodeling is crucial for many cellular physiological processes, including the repair of DNA double-strand break (DSB). While the mechanism of DSB repair is well understood, the connection between chromatin remodeling and DSB repair remains incompletely elucidated. In this review, we aim to highlight recent studies demonstrating the close relationship between chromatin remodeling and DSB repair. We summarize the impact of DSB repair on chromatin, including nucleosome arrangement, chromatin organization, and dynamics, and conversely, the role of chromatin architecture in regulating DSB repair. Additionally, we also summarize the contribution of chromatin remodeling complexes to cancer biology through DNA repair and discuss their potential as therapeutic targets for cancer.

引用

页数：9

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