Natural killer cells: a new promising source for developing chimeric antigen receptor anti-cancer cells in hematological malignancies

被引：0
作者：
Mousavi, Shahrzad [1 ]
Khazaee-Nasirabadi, Mohammad Hossein [2 ]
Seyedmehdi, Maryam Sadat [3 ]
Bazi, Ali [2 ,4 ]
Khalilabadi, Roohollah Mirzaee [2 ]
机构：
[1] Tarbiat Modares Univ, Fac Med Sci, Dept Hematol, Tehran, Iran
[2] Kerman Univ Med Sci, Fac Allied Med, Dept Hematol & Med Lab Sci, Kerman, Iran
[3] Shahid Beheshti Univ, Fac Life Sci & Technol, Dept Cell & Mol Biol, Tehran, Iran
[4] Zabol Univ Med Sci, Fac Allied Med Sci, Zabol, Iran
来源：
LEUKEMIA & LYMPHOMA | 2024年
关键词：
Chimeric antigen receptor; CAR NK; NK; hematological malignancies; EX-VIVO EXPANSION; OFF-THE-SHELF; NK CELLS; T-CELLS; PERIPHERAL-BLOOD; LYMPHOCYTE SUBSETS; GENE-TRANSFER; NK-92; CELLS; LARGE-SCALE; LINE NK-92;
D O I：
10.1080/10428194.2024.2438802
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
In recent times, the application of CAR-T cell treatment has significantly progressed, showing auspicious treatment outcomes in hematologic malignancies. However, along with these advances, certain limitations and challenges hurdle the widespread utilization of this technology. Recently, CAR-NK cells have gained attention in cancer treatment, as this approach has an important advantage over CART therapy (i.e. no need for HLA matching) for targeting foreign cells. This review aims to explore the benefits of CAR NK cell therapy, and generation strategies, as well as the challenges and limitations hindering the application of CAR NK cells in experimental studies and trials on hematologic malignancies.
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页数：23
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