The associations between cardiovascular and pain responses to a cold pressor test differ between males and females

被引:0
作者
Bock, Joshua M. [1 ]
Hanson, Brady E. [2 ]
Miller, Kayla A. [2 ]
Casey, Darren P. [2 ,3 ,4 ]
机构
[1] Mayo Clin, Dept Cardiovasc Med, Rochester, MN USA
[2] Univ Iowa, Carver Coll Med, Dept Phys Therapy & Rehabil Sci, Iowa City, IA 52242 USA
[3] Univ Iowa, Carver Coll Med, Abboud Cardiovasc Ctr, Iowa City, IA 52242 USA
[4] Univ Iowa, Carver Coll Med, Fraternal Order Eagles Diabet Res Ctr, Iowa City, IA 52242 USA
基金
美国国家卫生研究院;
关键词
Sex; Blood pressure; Pain; Sympathetic activation; BLOOD-PRESSURE; HYPERTENSION; WOMEN;
D O I
10.1007/s00421-025-05703-7
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Nociceptors contribute to the cardiovascular responses during a cold pressor test (CPT). While these responses are lower in females, data suggest that they perceive the CPT as more painful. Thus, we examined sex differences in associations between pain and cardiovascular responses to a CPT (Aim 1) as well as differences between females using (OC), and not using (NC), an oral contraceptive (Aim 2). 25 males (23 +/- 5 years) and 25 females (21 +/- 3 years; 11OC and 14NC) were studied. Cardiovascular data and pain levels (0-10 scale) were recorded at baseline then during a two-minute CPT; changes from baseline to peak response were analyzed. Systolic blood pressure (SBP, p = 0.57), mean arterial pressure (MAP, p = 0.22), heart rate (HR, p = 0.58), and pain (p = 0.71) responses did not differ between sexes; diastolic blood pressure (DBP) increased more in males (17 +/- 8 vs. 13 +/- 6 mmHg, p < 0.05). Pain was associated with HR in males (r = 0.42, p < 0.05) but not females (r = -0.16, p = 0.44); no other associations were observed in either sex (p = 0.48-0.92). SBP (27 +/- 12 vs. 15 +/- 6 mmHg), DBP (16 +/- 6 vs. 9 +/- 5 mmHg), MAP (20 +/- 7 vs. 14 +/- 5 mmHg), and HR (8 +/- 5 vs. 2 +/- 5 beats/min) were greater in NC than OC (p < 0.05 for all); pain was similar (p = 0.38). In NC, pain was associated with DBP (r = 0.65, p = 0.01) and MAP (r = 0.65, p = 0.01), but not HR (r = -0.43, p = 0.13), and tended to be associated with SBP (r = 0.46, p = 0.09). In OC, pain was inversely associated with SBP (r = -0.62, p < 0.05) but no other outcome (p = 0.40-0.65). We report a sexual dimorphism in the HR-pain association during a CPT and underscore the impact of oral contraceptives.
引用
收藏
页数:10
相关论文
共 26 条
  • [1] A COMPARISON OF CARDIOVASCULAR AND AUTONOMIC ADJUSTMENTS TO 3 TYPES OF COLD STIMULATION TASKS
    ALLEN, MT
    SHELLEY, KS
    BOQUET, AJ
    [J]. INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY, 1992, 13 (01) : 59 - 69
  • [2] Women have lower tonic autonomic support of arterial blood pressure and less effective baroreflex buffering than men
    Christou, DD
    Jones, PP
    Jordan, J
    Diedrich, A
    Robertson, D
    Seals, DR
    [J]. CIRCULATION, 2005, 111 (04) : 494 - 498
  • [3] Sex differences in sympathetic neurovascular and neurohemodynamic relationships during cold pressor test
    Coovadia, Yasmine
    Adler, Tessa E.
    Martin-Arrowsmith, Patrick W.
    Usselman, Charlotte W.
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 2022, 322 (05) : R411 - R420
  • [4] Menstrual cycle hormones and oral contraceptives: a multimethod systems physiology-based review of their impact on key aspects of female physiology
    D'Souza, Alysha C.
    Wageh, Mai
    Williams, Jennifer S.
    Colenso-Semple, Lauren M.
    McCarthy, Devin G.
    McKay, Alannah K. A.
    Elliott-Sale, Kirsty J.
    Burke, Louise M.
    Parise, Gianni
    MacDonald, Maureen J.
    Tarnopolsky, Mark A.
    Phillips, Stuart M.
    [J]. JOURNAL OF APPLIED PHYSIOLOGY, 2023, 135 (06) : 1284 - 1299
  • [5] Associations of Oral Contraceptive Use With Cardiovascular Disease and All-Cause Death: Evidence From the UK Biobank Cohort Study
    Dou, Weijuan
    Huang, Yan
    Liu, Xuesong
    Huang, Chensihan
    Huang, Junlin
    Xu, Bingyan
    Yang, Linjie
    Liu, Yating
    Lei, Xuzhen
    Li, Xu
    Huang, Junfeng
    Lin, Jiayang
    Liu, Deying
    Zhang, Peizhen
    Shao, Jiaqing
    Liu, Changqin
    Zhang, Huijie
    [J]. JOURNAL OF THE AMERICAN HEART ASSOCIATION, 2023, 12 (16):
  • [6] Pain perception to the cold presser test during the menstrual cycle in relation to estrogen levels and a comparison with men
    Hellström, B
    Lundberg, U
    [J]. INTEGRATIVE PHYSIOLOGICAL AND BEHAVIORAL SCIENCE, 2000, 35 (02) : 132 - 141
  • [7] Cold pressor test in spinal cord injury-revisited
    Hubli, Michele
    Bolt, Doris
    Krassioukov, Andrei V.
    [J]. SPINAL CORD, 2018, 56 (06) : 528 - 537
  • [8] Effect of oral hormonal contraceptive pill use on the hemodynamic response to the cold pressor test
    Jacob, Dain W.
    Voshage, Aaron M.
    Harper, Jennifer L.
    Limberg, Jacqueline K.
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2022, 322 (06): : H1072 - H1079
  • [9] Elevated Heart Rate and Pain During a Cold Pressor Test Correlates to Pain Catastrophizing
    Kakon, Gabriel
    Mohamadi, Amir-Arshiya Kaffash
    Levtova, Natalie
    Maurice-Ventouris, Meagane E., I
    Benoit, Emilie-Anne
    Chouchou, Florian
    Darlington, Peter J.
    Dover, Geoffrey
    [J]. APPLIED PSYCHOPHYSIOLOGY AND BIOFEEDBACK, 2021, 46 (04) : 359 - 366
  • [10] RELATION BETWEEN COLD PRESSER TEST AND DEVELOPMENT OF HYPERTENSION BASED ON 28-YEAR FOLLOW-UP
    KASAGI, F
    AKAHOSHI, M
    SHIMAOKA, K
    [J]. HYPERTENSION, 1995, 25 (01) : 71 - 76