S100A12 inhibits Streptococcus pneumoniae and aids in wound healing of corneal epithelial cells both in vitro and in vivo

被引：0
作者：
Mishra, Priyasha [1 ,2 ,3 ]
Ch, Sanjay [4 ]
Ghosh, Abhijit [1 ,2 ]
Kundu, Srijita [1 ,2 ,3 ]
Agarwal, Riddhi [1 ,2 ,3 ]
Bhogapurapu, Bharathi [1 ]
Biswas, Swati [4 ]
Roy, Sanhita [1 ,2 ]
机构：
[1] LV Prasad Eye Inst, Prof Brien Holden Eye Res Ctr, Hyderabad 500034, India
[2] LV Prasad Eye Inst, Dr Chigurupati Nageswara Rao Ocular Pharmacol Res, Hyderabad, India
[3] Manipal Acad Higher Educ, Manipal, India
[4] Birla Inst Technol & Sci Pilani, Dept Pharm, Hyderabad Campus, Hyderabad, India
来源：
MICROBES AND INFECTION | 2025年 / 27卷 / 02期
关键词：
Antimicrobial peptides; Streptococcus; Zeta potential; Wound healing; EXPRESSION; GROWTH;
D O I：
10.1016/j.micinf.2024.105421
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Streptococcus pneumoniae, a leading cause of corneal infections worldwide, are extremely aggressive despite antibiotic sensitivity and exhibit increased resistance towards antibiotics. Antimicrobial peptides are often considered as potent alternatives against antibiotic resistance and here we have investigated the possible roles of S100A12, a host defense peptide, in wound healing and S. pneumoniae infection. S100A12 significantly inhibited growth of S. pneumoniae by disruption of membrane integrity along with increased generation of reactive oxygen species. Additionally, S100A12 accelerated cell migration and wound closure in human corneal epithelial cells and in a murine corneal wound model by activation of EGFR and MAPK signaling pathways.
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页数：7
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