Fungal microbiota in COPD patients during exacerbations

被引：0

作者：

Gawor, Weronika ^{[1
]}

Goralska, Katarzyna ^{[2
]}

Galant, Sandra

Majewski, Sebastian ^{[3
]}

Piotrowski, Wojciech ^{[3
]}

Milkowska-Dymanowska, Joanna ^{[3
]}

Kiszalkiewicz, Justyna ^{[1
]}

Brzezianska-Lasota, Ewa ^{[1
]}

机构：

[1] Med Univ Lodz, Chair Biol & Med Microbiol, Dept Biomed & Genet, Mazowiecka St 5, PL-92215 Lodz, Poland

[2] Med Univ Lodz, Chair Biol & Med Microbiol, Dept Biol & Parasitol, Lucjan Zeligowskiego 7-9 St, PL-90752 Lodz, Poland

[3] Univ Lodz, Dept Pneumol Med, Stefan Kopcinski 22 St, PL-90153 Lodz, Poland

来源：

JOURNAL DE MYCOLOGIE MEDICALE | 2025年 / 35卷 / 02期

关键词：

COPD; Mycobiota; Acute exarbation; Multifocal fungal colonization; Anti-mannan antibodies; OBSTRUCTIVE PULMONARY-DISEASE; INVASIVE CANDIDIASIS; INTERNAL-MEDICINE; NATURAL-HISTORY; EPIDEMIOLOGY; CANDIDEMIA; COLONIZATION; PATHOGENESIS; DEFINITION; MANAGEMENT;

D O I：

10.1016/j.mycmed.2025.101543

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Acute exacerbations of chronic obstructive pulmonary disease (COPD) results in increased mortality and can be triggered by a range of factors, including microorganisms. Very little studies have examined the role of fungi and fungal diversity in COPD patients. The aim of the study was to determine the role of Candida in COPD during an exacerbation. Oral swabs, sputum, feces and whole blood samples were collected from the AECOPD patients and control group. Mycological and serological analysis were performed. Yeast were statistically significantly more often isolated from the AECOPD group (97.06%) than from the control group (26.32%). 7 species were isolated from the AECOPD, and 3 from the control group. Dominated Candida albicans followed by C. tropicalis. a-diversity was much greater in AECOPD patients than in controls. b-diversity was also assessed. A much higher level of antimycotic resistance was observed in isolates from the AECOPD group, which affects the effectiveness of therapy. Serological tests showed twice the frequency of positive results in the AECOPD group. The mycobiota of AECOPD patients is numerically and taxonomically richer than controls, including species less frequently recorded in humans. Our research confirms that fungal mycobiota may be a potential factor influencing the development of exacerbations and progression of COPD. (c) 2025 Published by Elsevier Masson SAS on behalf of SFMM.

引用

页数：15

共 71 条

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