Next-generation biomarkers for alcohol consumption and alcohol use disorder diagnosis, prognosis, and treatment: A critical review

被引：0
作者：
Clark, Shaunna L. [1 ]
Hartwell, Emily E. [2 ,3 ]
Choi, Doo-Sup [4 ,5 ,6 ]
Krystal, John H. [7 ]
Messing, Robert O. [8 ,9 ,10 ]
Ferguson, Laura B. [8 ,9 ,10 ]
机构：
[1] Texas A&M Univ, Dept Psychiat & Behav Sci, College Stn, TX USA
[2] Crescenz Vet Affairs Med Ctr, Mental Illness Res Educ & Clin Ctr, Philadelphia, PA USA
[3] Univ Penn, Ctr Studies Addict, Perelman Sch Med, Dept Psychiat, Philadelphia, PA USA
[4] Mayo Clin, Coll Med & Sci, Dept Mol Pharmacol & Expt Therapeut, Rochester, MN USA
[5] Mayo Clin, Coll Med & Sci, Dept Psychiat & Psychol, Rochester, MN USA
[6] Mayo Clin, Coll Med & Sci, Neurosci Program, Rochester, MN USA
[7] Yale Univ, Sch Med, Dept Psychiat, New Haven, CT USA
[8] Univ Texas Austin, Waggoner Ctr Alcohol & Addict Res, 1601 Trinity St,HDB 5-322, Austin, TX 78712 USA
[9] Univ Texas Austin, Dell Med Sch, Dept Neurol, Austin, TX USA
[10] Univ Texas Austin, Dept Neurosci, Austin, TX USA
来源：
ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH | 2025年 / 49卷 / 01期
关键词：
alcohol; AUD; biomarkers; machine learning; omics; GENOME-WIDE ASSOCIATION; GENETIC UNDERPINNINGS; SOCIAL DRINKERS; DEPENDENCE; NALTREXONE; DRINKING; IDENTIFICATION; ACAMPROSATE; INDIVIDUALS; MEDICATIONS;
D O I：
10.1111/acer.15476
中图分类号：
R194 [卫生标准、卫生检查、医药管理];
学科分类号：
摘要：
This critical review summarizes the current state of omics-based biomarkers in the alcohol research field. We first provide definitions and background information on alcohol and alcohol use disorder (AUD), biomarkers, and "omic" technologies. We next summarize using (1) genetic information as risk/prognostic biomarkers for the onset of alcohol-related problems and the progression from regular drinking to problematic drinking (including AUD), (2) epigenetic information as diagnostic biomarkers for AUD and risk biomarkers for alcohol consumption, (3) transcriptomic information as diagnostic biomarkers for AUD, risk biomarkers for alcohol consumption, and (4) metabolomic information as diagnostic biomarkers for AUD, risk biomarkers for alcohol consumption, and predictive biomarkers for response to acamprosate in subjects with AUD. In the final section, the clinical implications of the findings are discussed, and recommendations are made for future research.
引用
收藏
页码：5 / 24
页数：20
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