Electrical homeostasis of the inner mitochondrial membrane potential

被引：0
|
作者：
Fahimi, Peyman [1 ,2 ,3 ]
Castanedo, Lazaro A. M. [1 ,4 ]
Vernier, P. Thomas [5 ]
Matta, Cherif F. [1 ,2 ,4 ,6 ]
机构：
[1] Mt St Vincent Univ, Dept Chem & Phys, Halifax, NS B3M2J6, Canada
[2] Univ Laval, Dept Chim, Quebec City, PQ G1V 0A6, Canada
[3] Dalhousie Univ, Dept Math & Stat, Halifax, NS B3H4R2, Canada
[4] St Marys Univ, Dept Chem, Halifax, NS B3H3C3, Canada
[5] Old Dominion Univ, Frank Reidy Res Ctr Bioelect, Norfolk, VA 23508 USA
[6] Dalhousie Univ, Dept Chem, Halifax, NS B3H4J3, Canada
来源：
PHYSICAL BIOLOGY | 2025年 / 22卷 / 02期
基金：
加拿大创新基金会; 加拿大自然科学与工程研究理事会;
关键词：
mitochondrial biophysics; mitochondrial homeostasis; electrical feedback control in biological systems; mitochondrial electric potential; chemiosmotic theory; ACTIVITY-RELATIONSHIP MODEL; CYTOCHROME-C-OXIDASE; RATE-LIMITING STEP; RESPIRATORY-CHAIN; QUANTITATIVE STRUCTURE; LIPID-MEMBRANES; ENERGY; VISCOSITY; VOLTAGE; FIELD;
D O I：
10.1088/1478-3975/adaa47
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The electric potential across the inner mitochondrial membrane must be maintained within certain bounds for the proper functioning of the cell. A feedback control mechanism for the homeostasis of this membrane potential is proposed whereby an increase in the electric field decreases the rate-limiting steps of the electron transport chain (ETC). An increase in trans-membrane electric field limits the rate of proton pumping to the inter-membrane gap by slowing the ETC reactions and by intrinsically induced electroporation that depolarizes the inner membrane. The proposed feedback mechanism is akin to a Le Chatelier's-type principle of trans-membrane potential feedback control.
引用
收藏
页数：12
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