Inhibition of the human mitochondrial ClpP protease as a novel strategy against multiple myeloma

被引:0
作者
Patrone, M. [1 ]
Di Pisa, F. [1 ]
Tosatto, L. [2 ]
Swuec, P. [2 ]
Perini, T. [1 ]
Resnati, M. [1 ]
Del Grosso, Erika [3 ]
Yudin, A. K. [4 ]
Schimmer, A. D. [5 ]
Cenci, S. [1 ]
Coscia, F. [2 ]
Degano, M. [1 ]
机构
[1] Univ Vita Salute San Raffaele, Via Olgettina 58, I-20132 Milan, Italy
[2] Human Technopole, Viale Rita Levi Montalcini 1, I-20157 Milan, Italy
[3] Univ Piemonte Orientale, Dipartimento Sci Farmaco, Lgo Donegani 2, I-28100 Novara, Italy
[4] Univ Toronto, Dept Chem, Davenport Res Labs, 80 St George St, Toronto, ON M5S 3H6, Canada
[5] Univ Hlth Network, Princess Margaret Canc Ctr, 610 Univ Ave, Toronto, ON M5G 2M9, Canada
来源
ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES | 2024年 / 80卷
关键词
D O I
暂无
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
引用
收藏
页数:1
相关论文
共 50 条
  • [31] RNA Polymerase I Inhibition with CX-5461 as a Novel Therapeutic Strategy to Target MYC in Multiple Myeloma
    Lee, Hans C.
    Wang, Hua
    Baladandayuthapani, Veerabhadran
    Lin, Heather
    He, Jin
    Jones, Richard J.
    Kuiatse, Isere
    Gu, Dongmin
    Wang, Zhiqiang
    Ma, Wencai
    Lim, John
    O'Brien, Sean
    Keats, Jonathan
    Yang, Jing
    Davis, Richard E.
    Orlowski, Robert Z.
    BRITISH JOURNAL OF HAEMATOLOGY, 2017, 177 (01) : 80 - 94
  • [32] Protease inhibition by novel fluoropeptidomimetics: A mechanism-based design strategy
    Kotra, Lakshmi P.
    Annedi, Subhash C.
    Majumder, Kanchana
    Wei, Lianhu
    Samson, Sheeba
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2006, 231
  • [33] The aspartyl protease DDI2 drives adaptation to proteasome inhibition in multiple myeloma
    Op, Melanie
    Ribeiro, Sergio T.
    Chavarria, Claire
    De Gassart, Aude
    Zaffalon, Lea
    Martinon, Fabio
    CELL DEATH & DISEASE, 2022, 13 (05)
  • [34] The aspartyl protease DDI2 drives adaptation to proteasome inhibition in multiple myeloma
    Mélanie Op
    Sérgio T. Ribeiro
    Claire Chavarria
    Aude De Gassart
    Léa Zaffalon
    Fabio Martinon
    Cell Death & Disease, 13
  • [35] Myc-Related Mitochondrial Activity as a Novel Target for Multiple Myeloma
    Ortiz-Ruiz, Alejandra
    Ruiz-Heredia, Yanira
    Luz Morales, Maria
    Aguilar-Garrido, Pedro
    Garcia-Ortiz, Almudena
    Valeri, Antonio
    Barcena, Carmen
    Garcia-Martin, Rosa Maria
    Garrido, Vanesa
    Moreno, Laura
    Gimenez, Alicia
    Angel Navarro-Aguadero, Miguel
    Velasco-Estevez, Maria
    Lospitao, Eva
    Cedena, Maria Teresa
    Barrio, Santiago
    Martinez-Lopez, Joaquin
    Linares, Maria
    Gallardo, Miguel
    CANCERS, 2021, 13 (07)
  • [36] The Pivotal Role of Glutaminolysis in Multiple Myeloma: Novel Strategies for Target Therapies Against Myeloma
    Okabe, Seiichi
    Tanaka, Yuko
    Gotoh, Akihiko
    BLOOD, 2021, 138
  • [37] Molecular sequelae of proteasome inhibition in human multiple myeloma cells
    Mitsiades, N
    Mitsiades, CS
    Poulaki, V
    Chauhan, D
    Fanourakis, G
    Gu, XS
    Bailey, C
    Joseph, M
    Libermann, TA
    Treon, SP
    Munshi, NC
    Richardson, PG
    Hideshima, T
    Anderson, KC
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (22) : 14374 - 14379
  • [38] Mitochondrial matrix protease ClpP agonists suppress breast cancer stem cell function by downregulating multiple stem cell regulatory mechanisms
    Greer, Yoshimi E.
    Hernandez, Lidia
    Voeller, Donna
    Chari, Raj
    Tang, Binwu
    Annunziata, Christina M.
    Gilbert, Sam
    Wakefield, Lalage
    Iwanowicz, Edwin
    Graves, Lee M.
    Lipkowitz, Stanley
    MOLECULAR CANCER THERAPEUTICS, 2021, 20 (12)
  • [39] Targeted Inhibition of Myeloperoxidase (MPO): A New Therapeutic Strategy for the Treatment of Multiple Myeloma
    Williams, Connor
    Noll, Jacqueline
    Harnas, Dylan
    Parkinson, Hayley
    Hewett, Duncan
    Wyllie, Kaitlin
    Cox, Thomas
    Zannettino, Andrew
    Vandyke, Kate
    Panagopoulos, Vasilios
    BLOOD, 2023, 142
  • [40] Targeted inhibition of the immunoproteasome is a potent strategy against models of multiple myeloma that overcomes resistance to conventional drugs and nonspecific proteasome inhibitors
    Kuhn, Deborah J.
    Hunsucker, Sally A.
    Chen, Qing
    Voorhees, Peter M.
    Orlowski, Marian
    Orlowski, Robert Z.
    BLOOD, 2009, 113 (19) : 4667 - 4676