S-Adenosylmethionine (SAMe) for Liver Health: A Systematic Review

被引:0
作者
Baden, Kyrie Eleyson R. [1 ]
McClain, Halley [1 ]
Craig, Eliya [1 ]
Gibson, Nathan [1 ]
Draime, Juanita A. [1 ]
Chen, Aleda M. H. [1 ]
机构
[1] Cedarville Univ, Sch Pharm, Cedarville, OH 45314 USA
关键词
S-adenosylmethionine; SAMe; liver; nutraceutical; ADENOSYL-L-METHIONINE; URSODEOXYCHOLIC ACID; CONTROLLED-TRIAL; DISEASE; HEPATITIS; EFFICACY;
D O I
10.3390/nu16213668
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Background/Objectives: S-adenosylmethionine (SAMe) is a natural compound implicated in the treatment of liver dysfunction. In this systematic review, our objective was to determine the efficacy, safety, and optimal dose of SAMe in liver diseases. Methods: Using the PRISMA methodology, we searched PubMed, CINAHL, and Web of Science using key MeSH search terms. For title/abstract screening, full-text review, and data extraction, two independent researchers reviewed articles, and a third researcher resolved conflicts. Data extraction also included a quality assessment of included articles. Results: Of the 1881 non-duplicated studies, 15 articles focusing on SAMe use in the liver were included. All included studies (n = 15) scored a 4 or 5 out of 5 points on the quality assessment, which indicated high study quality. Overall, SAMe was effective in improving liver-related parameters with few adverse events, which were primarily mild, transient gastrointestinal complaints. Conclusions: The most common doses were SAMe 1000 mg or 1200 mg per day with or without another treatment or natural supplement. Future studies are needed to assess long-term efficacy and safety data of SAMe and the optimal route of administration in liver diseases.
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页数:13
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