Risk Factors and Outcomes of Patients with Pseudomonas aeruginosa Bloodstream Infection in the Intensive Care Unit

被引：0

作者：

Caydasi, Ozge ^{[1
]}

Arsian, Eytup ^{[1
]}

Cetin, Ayse Sababli ^{[1
]}

Karadag, Fatma Yilmaz ^{[1
]}

Dede, Asiye Tuncel ^{[1
]}

Adiyeke, Esra ^{[2
]}

Gundogus, Narin ^{[3
]}

Engin, Derya Ozturk ^{[1
]}

机构：

[1] Sancaktepe Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Sarigazi Ave, Istanbul, Turkiye

[2] Sancaktepe Res & Training Hosp, Dept Anesthesiol & Reanimat, Istanbul, Turkiye

[3] Sancaktepe Res & Training Hosp, Dept Med Microbiol, Istanbul, Turkiye

来源：

JUNDISHAPUR JOURNAL OF MICROBIOLOGY | 2024年 / 17卷 / 08期

关键词：

Pseudomonas aeruginosa; Difficult-to-Treat Resistance; Mortality; Carbapenem Exposure; Risk Factors; MORTALITY; RESISTANCE;

D O I：

10.5812/jjm-150331

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Background: Bloodstream infections (BSIs) caused by Pseudomonas aeruginosa have high mortality rates and pose a significant threat to healthcare settings. Objectives: We aimed to investigate the clinical risk factors related to mortality and the development of P. aeruginosa with difficult-to-treat resistance (DTR-PA) Methods: This was a retrospective, single-center study that included patients with P. aeruginosa BSI who were hospitalized between 2020 and 2022. The risk factors affecting 30-day mortality and the development of DTR-PA were investigated using both univariate and multivariate analyses. Results: A total of 140 patients were analyzed. The mean age was (66 +/- 17.5) years, and 48% of the patients were male. Previous meropenem use was an independent risk factor for DTR-PA BSI (odds ratio, 2.68; 95% CI, 1.24 to 5.80; P = 0.012). Multivariate analysis demonstrated that the requirement for inotropic support was an independent risk factor for 30-day mortality [hazard ratio, 2.50; 95% confidence interval (CI),1.33 to 4.68; P= 0.004].

引用

页数：7

共 28 条

[1] Antimicrobial Resistance Patterns and Prevalence of blaPER-1 and blaVEB-1 Genes Among ESBL-producing Pseudomonas aeruginosa Isolates in West of Iran [J].

Alikhani, Mohammad Yousef ;

Tabar, Zahra Karimi ;

Mihani, Fatemeh ;

Kalantar, Enayat ;

Karami, Pegman ;

Sadeghi, Mahnaz ;

Khosroshahi, Shiva Ahdi ;

Farajnia, Safar .

JUNDISHAPUR JOURNAL OF MICROBIOLOGY, 2014, 7 (01)

[2] Mortality burden related to infection with carbapenem-resistant Gram-negative bacteria among haematological cancer patients: a retrospective cohort study [J].

Andria, Nizar ;

Henig, Oryan ;

Kotler, Offer ;

Domchenko, Alexander ;

Oren, Ilana ;

Zuckerman, Tsila ;

Ofran, Yishai ;

Fraser, Drora ;

Paul, Mical .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2015, 70 (11) :3146-3153

[3] Epidemiology and risk factors of 28-day mortality of hospital-acquired bloodstream infection in Turkish intensive care units: a prospective observational cohort study [J].

Aslan, Abdullah Tarik ;

Tabah, Alexis ;

Koylu, Bahadir ;

Kalem, Ayse Kaya ;

Aksoy, Firdevs ;

Erol, Cigdem ;

Karaali, Ridvan ;

Tunay, Burcu ;

Guzeldag, Seda ;

Batirel, Ayse ;

Dindar, Emine Kubra ;

Akdogan, Ozlem ;

Bilir, Yeliz ;

Ersoz, Gulden ;

Ozturk, Barcin ;

Selcuk, Mehtap ;

Yilmaz, Mesut ;

Akyol, Ahmet ;

Akbas, Turkay ;

Sungurtekin, Hulya ;

Timuroglu, Arif ;

Gurbuz, Yunus ;

Colak, Onur ;

Bayindir, Yasar ;

Eroglu, Ahmet ;

Ferlicolak, Leyla ;

Cesme, Utku ;

Dag, Osman ;

Buetti, Niccolo ;

Barbier, Francois ;

Ruckly, Stephane ;

Staiquly, Quentin ;

Timsit, Jean-Francois ;

Akova, Murat .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2023, 78 (07) :1757-1768

[4] Changes in antimicrobial resistance and outcomes of health care-associated infections [J].

Aydin, Mehtap ;

Azak, Emel ;

Bilgin, Huseyin ;

Menekse, Sirin ;

Asan, Ali ;

Mert, Habibe Tulin Elmaslar ;

Yulugkural, Zerrin ;

Altunal, Lutfiye Nilsun ;

Hatipoglu, Cigdem Ataman ;

Ertem, Gunay Tuncer ;

Altunok, Elif Sargin ;

Demirkaya, Melike Hamiyet ;

Ceviker, Sevil Alkan ;

Akgul, Fethiye ;

Memis, Zeynep ;

Konya, Petek ;

Azap, Alpay ;

Aydin, Gule ;

Korkmaz, Derya ;

Karakoc, Zehra Cagla ;

Yapar, Derya ;

Karakecili, Faruk ;

Gunal, Ozgur ;

Keske, Siran ;

Kapmaz, Mahir ;

Kader, Cigdem ;

Demirel, Aslihan ;

Ergonul, Onder .

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 2021, 40 (08) :1737-1742

[5] Derivation of a quick Pitt bacteremia score to predict mortality in patients with Gram-negative bloodstream infection [J].

Battle, Sarah E. ;

Augustine, Matthew R. ;

Watson, Christopher M. ;

Bookstaver, P. Brandon ;

Kohn, Joseph ;

Owens, William B. ;

Baddour, Larry M. ;

Al-Hasan, Majdi N. .

INFECTION, 2019, 47 (04) :571-578

[6]

Centers for Disease Control, 2023, Bloodstream infection event (central line-associated bloodstream infection and non-central line-associated bloodstream infection)

[7] Charlson Comorbidity Index: A Critical Review of Clinimetric Properties [J].

Charlson, Mary E. ;

Carrozzino, Danilo ;

Guidi, Jenny ;

Patierno, Chiara .

PSYCHOTHERAPY AND PSYCHOSOMATICS, 2022, 91 (01) :8-35

[8] Registry-Based Retrospective Cohort Study of Mortality among Adults Admitted to Intensive Care Units in Istanbul with Hospital Acquired Pseudomonas aeruginosa Bloodstream-Infection between 2014-2021 [J].

Derin, Okan ;

Sahin, Meyha ;

Dumlu, Ridvan ;

Basgonul, Sedef ;

Bayrak, Ahmet Dogukan ;

Arduc, Sevval ;

Bayram, Sumeyye ;

Mikaliyova, Nurlana ;

Kanturk, Arzu ;

Oncul, Ahsen ;

Sevgi, Dilek Yildiz ;

Gencer, Serap ;

Bayraktar, Banu ;

Dokmetas, Ilyas ;

Mert, Ali .

ANTIBIOTICS-BASEL, 2024, 13 (01)

[9] A 5-year surveillance of healthcare-associated infections in a university hospital: A retrospective analysis [J].

Erdem, Ilknur ;

Yildirim, Ilker ;

Safak, Birol ;

Karaali, Ritvan ;

Erdal, Berna ;

Ardic, Enes ;

Dogan, Mustafa ;

Kardan, M. Enes ;

Kavak, Caglar ;

Karadil, Kubra Sahin ;

Yildiz, Emre ;

Topcu, Birol ;

Kiraz, Nuri ;

Arar, Cavidan .

SAGE OPEN MEDICINE, 2022, 10

[10]

European Committee on Antimicrobial Susceptibility Testing, 2022, Breakpoints tables for interpretation of MICs and zone diameters

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