Potential role of thymoquinone to treat gastrointestinal cancers: insights into its molecular mechanisms

被引：0

作者：

Rahjoo, Tina ^{[1
,2
]}

Motamedzadeh, Alireza ^{[3
]}

Ferdosi, Felora ^{[4
]}

Dadgostar, Ehsan ^{[5
,6
]}

Aschner, Michael ^{[7
]}

Mirzaei, Hamed ^{[8
]}

Ghesmatpour, Sina ^{[1
,2
]}

Nabavizadeh, Fatemeh ^{[1
,2
]}

Rahmati-Dehkordi, Fatemeh ^{[9
]}

Tamtaji, Omid Reza ^{[1
,2
]}

机构：

[1] Univ Tehran Med Sci, Neurosci Inst, Electrophysiol Res Ctr, Tehran, Iran

[2] Univ Tehran Med Sci, Sch Med, Dept Physiol, Tehran, Iran

[3] Kashan Univ Med Sci, Fac Med, Dept Internal Med, Kashan, Iran

[4] Isfahan Univ Med Sci, Sch Med, Dept Radiol, Esfahan, Iran

[5] Isfahan Univ Med Sci, Behav Sci Res Ctr, Esfahan, Iran

[6] Isfahan Univ Med Sci, Student Res Comm, Esfahan, Iran

[7] Albert Einstein Coll Med, Dept Mol Pharmacol, Bronx, NY 10461 USA

[8] Kashan Univ Med Sci, Res Ctr Biochem & Nutr Metab Dis, Kashan, Iran

[9] Univ Tehran Med Sci, Students Sci Res Ctr, Tehran, Iran

来源：

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY | 2025年 / 398卷 / 08期

关键词：

Thymoquinone; Gastrointestinal neoplasms; Nanotechnology; Apoptosis; Metastasis; MEDIATED MULTIDRUG-RESISTANCE; LOVO COLON-CANCER; GASTRIC-CANCER; HEPATOCELLULAR-CARCINOMA; NIGELLA-SATIVA; OXIDATIVE STRESS; IN-VITRO; CELL-DEATH; INHIBITION; APOPTOSIS;

D O I：

10.1007/s00210-025-03861-1

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Gastrointestinal (GI) malignancies, including esophageal cancer, gastric cancer, and colon cancer, are associated with high mortality rates worldwide. Thymoquinone is one of the main bioactive components of Nigella sativa, and it has been documented to have anticancer effects including GI cancer. Thymoquinone inhibits GI cancer progression by inducing cell cycle arrest, apoptosis, and oxidative stress and inhibiting inflammation, migration, invasion, metastasis, histone deacetylases, STAT3, PI3K/AKT/mTOR, and Wnt/beta-catenin signaling pathways. Although the beneficial effects of thymoquinone have been documented, some limitations, including poor bioavailability and hydrophobicity, have hindered its clinical application. Nanotechnology approaches bypass these limitations. In this review article, we outline the different cellular and molecular pathways influenced by thymoquinone and its nanoformulations in GI cancer.

引用

页码：9471 / 9497

页数：27

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