Impact of body mass index as a continuous variable on short- and long-term outcomes in patients undergoing laparoscopic surgery for colon cancer

被引：0

作者：

Aiba, Takayuki ^{[1
]}

Akagi, Tomonori ^{[1
]}

Shiroshita, Hidefumi ^{[1
]}

Nakajima, Kentaro ^{[2
]}

Ohyama, Tetsuji ^{[3
]}

Kinjo, Tatsuya ^{[4
]}

Kanazawa, Akiyoshi ^{[5
]}

Suzuki, Nobuaki ^{[6
]}

Tokunaga, Takuya ^{[7
]}

Yamamoto, Manabu ^{[8
]}

Ichikawa, Nobuki ^{[9
]}

Endo, Shungo ^{[10
]}

Kojima, Yutaka ^{[11
]}

Nakamura, Takatoshi ^{[12
]}

Saito, Shuji ^{[13
]}

Kagawa, Yoshinori ^{[14
]}

Ohnuma, Shinobu ^{[15
]}

Yamamoto, Seiichiro ^{[16
]}

Naitoh, Takeshi ^{[17
]}

Inomata, Masafumi ^{[1
]}

机构：

[1] Oita Univ, Fac Med, Dept Gastroenterol & Pediat Surg, 1-1 Idaigaoka, Yufu, Oita 8795593, Japan

[2] NTT Med Ctr Tokyo, Dept Pathol, Shinagawa Ku, Tokyo, Japan

[3] Kurume Univ, Biostat Ctr, Fukuoka, Japan

[4] Niigata City Gen Hosp, Dept Digest Surg, Nishihara, Japan

[5] Shimane Prefectural Cent Hosp, Dept Surg, Izumo, Japan

[6] Yamaguchi Univ, Dept Gastroenterol Breast & Endocrine Surg, Grad Sch Med, Ube, Japan

[7] Tokushima Univ Hosp, Dept Digest & Transplant Surg, Tokushima, Japan

[8] Tottori Univ, Fac Med, Dept Surg, Div Gastrointestinal & Pediat Surg, Yonago, Japan

[9] Hokkaido Univ, Grad Sch Med, Dept Gastroenterol Surg 1, Sapporo, Japan

[10] Fukushima Med Univ, Dept Coloproctol, Aizu Med Ctr, Fukushima, Japan

[11] Juntendo Univ, Fac Med, Dept Coloproctol Surg, Bunkyo Ku, Tokyo, Japan

[12] Dokkyo Med Univ, Dept Colorectal Surg, Tochigi, Japan

[13] Yokohama Shin Midori Gen Hosp, Gastrointestinal Ctr, Div Surg, Yokohama, Japan

[14] Osaka Int Canc Inst, Dept Gastroenterol Surg, Osaka, Japan

[15] Tohoku Univ, Grad Sch Med, Dept Surg, Sendai, Japan

[16] Tokai Univ, Sch Med, Sch Med, Shibuya, Japan

[17] Kitasato Univ, Sch Med, Dept Lower Gastrointestinal Surg, Sagamihara, Japan

来源：

ANNALS OF GASTROENTEROLOGICAL SURGERY | 2025年 / 9卷 / 03期

关键词：

body mass index; colon cancer; continuous variable; laparoscopic surgery; obesity paradox; RECTAL-CANCER; OBESITY; SURVIVAL; BMI;

D O I：

10.1002/ags3.12916

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Background: The impact of obesity on colon cancer remains unclear. Very few studies of colon cancer surgery have analyzed body mass index (BMI) as a continuous variable, with no such reports from Japan. This study examined the association between BMI as a continuous variable and short- and long-term outcomes of laparoscopic surgery for obese colon cancer patients. Methods: Obese (BMI >= 25 kg/m2) patients who underwent laparoscopic radical surgery for Stage II/III colon cancer at 46 participating centers from 2009 to 2013 were included. Associations between short- and long-term outcomes and BMI as a continuous variable were analyzed by univariate and multivariate regression models. Results: Among patients meeting the study criteria, 1036 were examined. BMI as a continuous variable correlated with log-transformed operative time (regression coefficient: 0.02, 95% confidence interval [CI]: 0.012-0.028, p < 0.05) and blood loss (odds ratio: 1.089, 95% CI: 1.032-1.149, p < 0.05). There was no association between BMI continuous variables and 3-year relapse-free survival (RFS) and overall survival. However, 3-year RFS was possibly better in patients with BMI >= 28.5 kg/m2 versus those with BMI <28.5 kg/m2 (hazard ratio: 0.682, 95% CI: 0.462-1.008, p = 0.055). Conclusions: This study showed that BMI as a continuous variable correlated with operative time and blood loss. RFS was possibly better in the severely obese patients (BMI >= 28.5 kg/m2), suggesting that the prognosis for highly obese colon cancer patients appears to follow the obesity paradox.

引用

页码：392 / 400

页数：9

共 21 条

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