Hippocampal atrophy over two years in relation to tau, amyloid-(3 and memory in older adults

被引：0

作者：

Aumont, Etienne ^{[1
]}

Bedard, Marc-Andre ^{[2
,3
]}

Bussy, Aurelie

Arias, Jaime Fernandez ^{[2
]}

Tissot, Cecile ^{[2
,3
,6
,7
]}

Hall, Brandon J. ^{[2
,3
,6
]}

Therriault, Joseph ^{[2
,3
,6
]}

Rahmouni, Nesrine ^{[2
,3
,6
]}

Stevenson, Jenna ^{[2
,3
,6
]}

Servaes, Stijn ^{[2
,3
,6
]}

Macedo, Arthur C. ^{[2
,3
,6
]}

Vitali, Paolo ^{[2
,3
,6
]}

Poltronetti, Nina Margherita ^{[2
]}

Fliaguine, Olga ^{[1
]}

Trudel, Lydia ^{[2
,3
,6
]}

Gauthier, Serge ^{[2
,3
,6
]}

Chakravarty, Mallar M. ^{[4
,5
,8
]}

Rosa-Neto, Pedro ^{[2
,6
]}

机构：

[1] Univ Quebec Montreal UQAM, NeuroQAM Res Ctr, Montreal, PQ H2X 3P2, Canada

[2] MCGILL UNIV, Res Ctr Studies Aging, 6825 Blvd LaSalleVerdu, MONTREAL, PQ H4H 1R3, Canada

[3] McGill Univ, Montreal Neurol Inst, Montreal, PQ H3A 2B4, Canada

[4] Douglas Res Ctr, Cerebral Imaging Ctr, Montreal, PQ H4H 1R3, Canada

[5] Computat Brain Anat CoBrALab Lab, Montreal, PQ H4H 1R3, Canada

[6] McGill Univ, Dept Neurol & Neurosurg, Montreal, PQ H3A 1A1, Canada

[7] Lawrence Berkeley Natl Lab, Berkeley, CA 94720 USA

[8] McGill Univ, Dept Psychiat, Montreal, PQ H3A 1A1, Canada

来源：

NEUROBIOLOGY OF AGING | 2025年 / 146卷

基金：

加拿大自然科学与工程研究理事会;

关键词：

Hippocampus; Alzheimer's disease; Longitudinal; Tauopathy; Hippocampal subfields; Memory; ALZHEIMERS-DISEASE; BETA; PATHOLOGY; NEURODEGENERATION; ASSOCIATIONS; F-18-AZD4694; PERFORMANCE; CONVERSION; DEMENTIA; TANGLES;

D O I：

10.1016/j.neurobiolaging.2024.11.007

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

In this longitudinal brain imaging study, we aimed to characterize hippocampal tau accumulation and subfield atrophy relative to cortical amyloid-(3 and memory performance. We measured tau-PET in regions associated with Braak stages I to VI, global amyloid-PET burden, hippocampal subfield volumes and memory assessments from 173 participants aged 55-85. Eighty-six of these participants were tested again two years later. Tau-PET change in the Braak II region, corresponding to the hippocampus and the entorhinal cortex, was significantly associated with the cornu ammonis 1 (CA1) atrophy and memory score. This CA1 atrophy did not significantly mediate the association between tau and memory, nor did global amyloid-PET burden correlate with tau-PET changes in the Braak II region. Longitudinal hippocampal tau accumulation is amyloid-(3-independent and colocalized with subfield atrophy. As tau-associated memory decline seems to be independent from hippocampal atrophy, other mechanisms could contribute to the deficit.

引用

页码：48 / 57

页数：10

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