Genetic Etiology Link to Brain Function Underlying ADHD Symptoms and its Interaction with Sleep Disturbance: An ABCD Study

被引：1

作者：

Feng, Aichen ^{[1
,2
,3
]}

Zhi, Dongmei ^{[4
]}

Fu, Zening ^{[5
,6
]}

Yu, Shan ^{[7
]}

Luo, Na ^{[1
,2
]}

Calhoun, Vince ^{[5
,6
]}

Sui, Jing ^{[4
]}

机构：

[1] Chinese Acad Sci, Brainnetome Ctr, Inst Automat, Beijing 100190, Peoples R China

[2] Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China

[3] Univ Chinese Acad Sci, Sch Artificial Intelligence, Beijing 100049, Peoples R China

[4] Beijing Normal Univ, IDG McGovern Inst Brain Res, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China

[5] Emory Univ, Georgia Inst Technol, Triinst Ctr Translat Res Neuroimaging & Data Sci, Atlanta, GA 30303 USA

[6] Georgia State Univ, Atlanta, GA 30303 USA

[7] Chinese Acad Sci, Lab Brain Atlas & Brain Inspired Intelligence, Inst Automat, Beijing 100190, Peoples R China

来源：

NEUROSCIENCE BULLETIN | 2025年 / 41卷 / 06期

基金：

中国国家自然科学基金; 中国博士后科学基金;

关键词：

Attention deficit hyperactivity disorder; Polygenic risk score; Sleep disturbance; Functional connectivity; Magnetic resonance imaging; ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; DEFAULT-MODE NETWORK; DEFICIT HYPERACTIVITY DISORDER; ENVIRONMENT INTERACTIONS; RESPONSE-INHIBITION; CHILDREN; RISK; FMRI; CONNECTIVITY; METAANALYSIS;

D O I：

10.1007/s12264-025-01349-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Attention deficit hyperactivity disorder (ADHD), a prevalent neurodevelopmental disorder influenced by both genetic and environmental factors, remains poorly understood regarding how its polygenic risk score (PRS) impacts functional networks and symptomology. This study capitalized on data from 11,430 children in the Adolescent Brain Cognitive Development study to explore the interplay between PRSADHD, brain function, and behavioral problems, along with their interactive effects. The results showed that children with a higher PRSADHD exhibited more severe attention deficits and rule-breaking problems, and experienced sleep disturbances, particularly in initiating and maintaining sleep. We also identified the central executive network, default mode network, and sensory-motor network as the functional networks most associated with PRS and symptoms in ADHD cases, with potential mediating roles. Particularly, the impact of PRSADHD was enhanced in children experiencing heightened sleep disturbances, emphasizing the need for early intervention in sleep issues to potentially mitigate subsequent ADHD symptoms.

引用

页码：1041 / 1053

页数：13

共 73 条

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