Origins and molecular effects of hypoxia in cancer

被引：5

作者：

Rey-Keim, Sergio ^{[1
,2
]}

Schito, Luana ^{[1
,2
]}

机构：

[1] Univ Coll Dublin, UCD Sch Med, Belfield D04 C7X2, Dublin, Ireland

[2] Univ Coll Dublin, UCD Conway Inst Biomol & Biomed Res, Belfield D04 C7X2, Dublin, Ireland

来源：

SEMINARS IN CANCER BIOLOGY | 2024年 / 106卷

关键词：

Oxygen sensing; Hypoxia; Cancer; Metastasis; Tumor microenvironment; Targeted therapy; Chemotherapy; Molecular medicine; SQUAMOUS-CELL CARCINOMA; PREDICTS RADIATION RESPONSE; INTERSTITIAL FLUID PRESSURE; MESSENGER-RNA TRANSLATION; TISSUE OXYGEN-TENSION; NECK NODE METASTASES; TUMOR OXYGENATION; INDUCIBLE FACTORS; BREAST-CANCER; BLOOD-FLOW;

D O I：

10.1016/j.semcancer.2024.10.001

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Hypoxia (insufficient O2) is a pivotal factor in cancer progression, triggering genetic, transcriptional, translational and epigenetic adaptations associated to therapy resistance, metastasis and patient mortality. In this review, we outline the microenvironmental origins and molecular mechanisms responsible for hypoxic cancer cell adaptations in situ and in vitro, whilst outlining current approaches to stratify, quantify and therapeutically target hypoxia in the context of precision oncology.

引用

页码：166 / 178

页数：13

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