Synthesis of new 1,2,3-triazole-linked pyrimidines by click reaction

被引：0
|
作者：
Cheldavi, Forough [1 ]
Bakherad, Mohammad [1 ]
Keivanloo, Ali [1 ]
Nikpour, Mohsen [2 ]
机构：
[1] Shahrood Univ Technol, Fac Chem, Shahrood 3619995161, Iran
[2] Islamic Azad Univ, Sch Sci, Dept Chem, Ahvaz Branch, Ahvaz, Iran
来源：
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS | 2024年 / 199卷 / 7-9期
关键词：
1,2,3-Triazole; pyrimidine; click reaction; copper catalyst; TERMINAL ALKYNES; SODIUM-AZIDE; ONE-POT; DERIVATIVES; INHIBITORS; INDOLES; HALIDES; DESIGN; WATER; ACIDS;
D O I：
10.1080/10426507.2024.2419630
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
A mild and efficient synthesis of 1,4-disubstituted 1,2,3-triazole linked pyrimidines is reported using click reactions. These compounds were prepared by the reaction of 4-propargyl substituted 5-iodo-6-methyl-2(methylthio) pyrimidine with aryl and benzyl azides via copper-catalyzed azide-alkyne cycloaddition reactions in the presence of sodium ascorbate, as a reducing agent. Furthermore, the synthesized compounds were screened against the two bacterial strains pseudomonas aeruginosa and saphylococcus aureus.
引用
收藏
页码：725 / 731
页数：7
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