Palladium-catalyzed carbon-carbon bond cleavage of primary alcohols: decarbonylative coupling of acetylenic aldehydes with haloarenes

被引：0

作者：

Jin, Zewei ^{[1
]}

Li, Qiang ^{[1
]}

Zhu, Maoshuai ^{[1
]}

Zhang, Yanqiong ^{[1
]}

Yan, Xufei ^{[2
,3
]}

Zhou, Xiangge ^{[1
]}

机构：

[1] Sichuan Univ, Coll Chem, 29 Wangjiang Rd, Chengdu 610064, Peoples R China

[2] Sichuan Univ, West China Sch Publ Hlth, Chengdu 610041, Peoples R China

[3] Sichuan Univ, West China Hosp 4, Chengdu 610041, Peoples R China

来源：

RSC ADVANCES | 2025年 / 15卷 / 10期

基金：

中国国家自然科学基金;

关键词：

INTERNAL ALKYNES; C-C; ACTIVATION; DIARYLACETYLENES; ELIMINATION; CYCLIZATION; LIBERATION;

D O I：

10.1039/d5ra00357a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In the current work, a palladium-catalyzed C-C bond cleavage reaction of primary alcohols has been developed. This transformation was characterized by a broad substrate scope, superior functional group tolerance, and high efficiency for selective C-C bond cleavage and was then followed by alkynyl-aryl cross coupling. Mechanism studies indicated that the propargyl alcohols underwent beta-H elimination to form aldehydes rather than having undergone beta-C elimination. The corresponding aldehyde intermediates then proceeded through a decarbonylation and coupling reaction with haloarenes to yield diarylacetylenes.

引用

页码：7826 / 7831

页数：6

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