Tumor microenvironment in oral squamous cell carcinoma

被引:4
作者
Li, Chenxi [1 ]
Dong, Xiaodan [1 ]
Li, Bo [1 ]
机构
[1] Jilin Univ, Hosp Stomatol, Dept Oral Anat & Physiol, Jilin Prov Key Lab Oral Biomed Engn, Changchun, Peoples R China
关键词
oral squamous cell carcinoma; tumor microenvironment; tumor-associated macrophages; interaction; cellular network; POOR-PROGNOSIS; MACROPHAGES; INFILTRATION; EXPRESSION; PROMOTES; HEAD;
D O I
10.3389/fimmu.2024.1485174
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Oral squamous cell carcinoma (OSCC) is a highly aggressive and malignant tumor of oral cavity with a poor prognosis and high mortality due to the limitations of existing therapies. The significant role of tumor microenvironment (TME) in the initiation, development, and progression of OSCC has been widely recognized. Various cells in TME, including tumor-associated macrophages (TAMs), cancer-associated fibroblasts (CAFs), T lymphocytes, tumor-associated neutrophils (TANs), myeloid-derived suppressor cells (MDSCs) and dendritic cells (DCs), form a complicated and important cellular network to modulate OSCC proliferation, invasion, migration, and angiogenesis by secreting RNAs, proteins, cytokines, and metabolites. Understanding the interactions among cells in TME provides the foundation for advanced clinical diagnosis and therapies. This review summarizes the current literature that describes the role of various cellular components and other TME factors in the progression of OSCC, hoping to provide new ideas for the novel OSCC treatment strategies targeting the complicated cellular network and factors that mediate the interactive loops among cells in TME.
引用
收藏
页数:14
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