Metal-free Cross-Dehydrogenative Coupling for α-Arylation of 3-Aryloxindoles

被引：0

作者：

Hu, Fangzhi ^{[1
,2
,3
]}

Wang, Peng ^{[2
]}

Li, Jiawei ^{[2
]}

Dong, Fengying ^{[2
]}

Jin, Long Yi ^{[1
]}

Li, Shuai-Shuai ^{[2
]}

机构：

[1] Yanbian Univ, Natl Demonstrat Ctr Expt Chem Educ, Dept Chem, Yanji 133002, Peoples R China

[2] Qingdao Agr Univ, Coll Chem & Pharmaceut Sci, Qingdao 266109, Peoples R China

[3] Hangzhou Foster Pharmaceut Co LTD, Hangzhou 310000, Peoples R China

来源：

CHEMISTRY-AN ASIAN JOURNAL | 2025年

基金：

中国国家自然科学基金;

关键词：

quaternary carbon centers; cross-dehydrogenative coupling; 3,3-diaryloxindoles; metal-free; arylation; NATURAL-PRODUCTS; TERTIARY-AMINES; INDOLES; FUNCTIONALIZATION; REARRANGEMENT; CONSTRUCTION; DERIVATIVES; ALKYLATION; CHEMISTRY; OXINDOLES;

D O I：

10.1002/asia.202500001

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The creation of quaternary carbon centers has been a formidable challenge in organic synthesis due to steric impediments, especially for the polyaryl substituted quaternary carbon centers. Up to now, a few of methods were reported for achieving the alpha-arylation of 3-aryloxindoles to construct 3,3-diaryloxindoles. We now asserted the TfOH-catalyzed cross-dehydrogenative coupling reaction between the tertiary C(sp3)-H and readily available arenes under air atmosphere in green reaction medium for rapid construction of 3,3-diaryloxindoles. In addition, the mechanism of the metal-free cross-dehydrogenative coupling with air as oxidant was meticulously explored.

引用

页数：7

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