Peptide-based amyloid-beta aggregation inhibitors

被引:0
作者
Sehra, Naina [1 ]
Parmar, Rajesh [1 ]
Jain, Rahul [1 ]
机构
[1] Natl Inst Pharmaceut Educ & Res, Dept Med Chem, Sect 67, Mohali 160062, Punjab, India
来源
RSC MEDICINAL CHEMISTRY | 2025年 / 16卷 / 03期
基金
新加坡国家研究基金会;
关键词
RETRO-INVERSO PEPTIDE; ALZHEIMERS-DISEASE; IN-VITRO; FIBRIL FORMATION; REDOX CHEMISTRY; CU-II; COPPER; TOXICITY; DESIGN; FIBRILLOGENESIS;
D O I
10.1039/d4md00729h
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Aberrant protein misfolding and accumulation is considered to be a major pathological pillar of neurodegenerative disorders, including Alzheimer's and Parkinson's diseases. Aggregation of amyloid-beta (A beta) peptide leads to the formation of toxic amyloid fibrils and is associated with cognitive dysfunction and memory loss in Alzheimer's disease (AD). Designing molecules that inhibit amyloid aggregation seems to be a rational approach to AD drug development. Over the years, researchers have utilized a variety of therapeutic strategies targeting different pathways, extensively studying peptide-based approaches to understand AD pathology and demonstrate their efficacy against A beta aggregation. This review highlights rationally designed peptide/mimetics, including structure-based peptides, metal-peptide chelators, stapled peptides, and peptide-based nanomaterials as potential amyloid inhibitors.
引用
收藏
页码:1083 / 1104
页数:22
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