Prevalence of Rheumatic Heart Disease in First-Degree Relatives of Index-Cases: A Systematic Review and Meta-Analysis

被引：0
作者：
Mutarelli, Antonio [1 ,2 ]
Nogueira, G. U. I. L. H. E. R. M. E. P. A. E. S. GONcALVES [1 ]
Pantaleao, Alexandre negrao [1 ]
Nogueira, Alleh [3 ]
Giavina-bianchi, Bruna [1 ,4 ,5 ]
Fonseca, Isabella m. gonzalez [5 ]
Nascimento, Bruno r. [6 ]
Dutra, Walderez o. [7 ,8 ]
Levine, Robert a. [9 ]
Nunes, Maria c. p. [1 ,5 ]
PRIMA NETWORK
机构：
[1] Univ Fed Minas Gerais, Sch Med, Belo Horizonte, Brazil
[2] Harvard Med Sch, Massachusetts Gen Hosp, Cardiac Ultrasound Lab, Boston, MA USA
[3] Univ Estadual Piaui, Teresina, Brazil
[4] Hosp Israelita Albert Einstein, Sao Paulo, SP, Brazil
[5] Univ Fed Minas Gerais, Serv Cardiol & Cirurgia Cardiaca, Hosp Clin, Belo Horizonte, MG, Brazil
[6] Hosp Madre Teresa, Serv Hemodinam, Belo Horizonte, MG, Brazil
[7] London Sch Hyg & Trop Med, Fac Infect & Trop Dis, London, England
[8] Inst Ciencias Biol, Lab Biol Interacoes Celulares, Dept Morfol, Belo Horizonte, MG, Brazil
[9] Harvard Med Sch, Massachusetts Gen Hosp, Cardiac Ultrasound Lab, Boston, MA USA
来源：
GLOBAL HEART | 2025年 / 20卷 / 01期
关键词：
Rheumatic heart disease; first-degree relative; family members; meta-analysis; FEVER; CHILDREN; RISK;
D O I：
10.5334/gh.1417
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Background: Rheumatic heart disease (RHD) is the leading cause of cardiac death in children, with over 300,000 annual fatalities. Immunological, genetic, and environmental factors contribute to an increased risk of RHD. It remains unclear whether first-degree relatives have a higher prevalence of RHD compared to the general population in the same region. Methods: We performed a systematic review and meta-analysis of echocardiographic screening studies reporting the prevalence of RHD in family members of individuals with RHD or acute rheumatic fever. PubMed, Embase, Cochrane, and Lilacs databases were searched. RHD was classified as per the 2012 World Heart Federation criteria. Random-effects models assessed definite RHD prevalence in study groups. Results: Four of the 1,160 studies were included, with 776 first-degree relatives screened. Two studies were from Africa, one from South America, and one from Oceania. In the first-degree relatives of index cases, the prevalence of RHD was 7% (95% confidence interval [CI] 3.7-13). The control group, individuals screened with no known RHD cases in their family, had a lower prevalence than first-degree relatives (risk ratio [RR] 0.44, 95% CI 0.26-0.75). There was no difference in the prevalence of RHD among siblings and parents of cases. Conclusion: There is an overall prevalence of non-relatives from the respective region, which suggests that genetic predisposition may play a role. In future studies of RHD, the systematic screening of first-degree relatives should be considered with a better control group-socioeconomic, region, age, and sex-matched.
引用
收藏
页数：10
相关论文
共 31 条
  • [1] Vervoort D, Jin H, Edwin F, Kumar RK, Malik M, Tapaua N, Et al., Global access to comprehensive care for paediatric and congenital heart disease, CJC Pediatr Congenit Heart Dis, 2, pp. 453-463, (2023)
  • [2] Shah SN, Sharma S., Mitral Stenosis, StatPearls [Internet], (2024)
  • [3] Ou Z, Yu D, Liang Y, Wu J, He H, Li Y, Et al., Global burden of rheumatic heart disease: trends from 1990 to 2019, Arthritis Research & Therapy, 24, 1, (2022)
  • [4] Ralph AP, Noonan S, Wade V, Currie BJ., The 2020 Australian guideline for prevention, diagnosis and management of acute rheumatic fever and rheumatic heart disease, Med J Aust, 214, 5, pp. 220-227, (2021)
  • [5] Beaton A, Okello E, Rwebembera J, Grobler A, Engelman D, Alepere J, Et al., Secondary antibiotic prophylaxis for latent rheumatic heart disease, N Engl J Med, 386, 3, pp. 230-240, (2022)
  • [6] Rothenbuhler M, O'Sullivan CJ, Stortecky S, Stefanini GG, Spitzer E, Estill J, Et al., Active surveillance for rheumatic heart disease in endemic regions: A systematic review and meta-analysis of prevalence among children and adolescents, Lancet Glob Health, 2, 12, pp. e717-e726, (2014)
  • [7] Muhamed B, Parks T, Sliwa K., Genetics of rheumatic fever and rheumatic heart disease, Nat Rev Cardiol, 17, 3, pp. 145-154, (2020)
  • [8] Tormin JPAS, Nascimento BR, Sable CA, da Silva JLP, Brandao-de-Resende C, Rocha LPC, Et al., Cytokine gene functional polymorphisms and phenotypic expression as predictors of evolution from latent to clinical rheumatic heart disease, Cytokine, 138, (2021)
  • [9] Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, Et al., The PRISMA 2020 statement: An updated guideline for reporting systematic reviews, BMJ, 372, (2021)
  • [10] Welch VA HJ., Cochrane Handbook for Systematic Reviews of Interventions version 6.4 (updated August 2023)
1234