The potential of natural products to inhibit abnormal aggregation of α-Synuclein in the treatment of Parkinson's disease

被引：2

作者：

Yang, Kaixia ^{[1
]}

Lv, Zhongyue ^{[1
]}

Zhao, Wen ^{[1
]}

Lai, Guogang ^{[1
]}

Zheng, Cheng ^{[2
]}

Qi, Feiteng ^{[1
]}

Zhao, Cui ^{[1
]}

Hu, Kaikai ^{[1
]}

Chen, Xiao ^{[1
]}

Fu, Fan ^{[1
]}

Li, Jiayi ^{[1
]}

Xie, Guomin ^{[1
]}

Wang, Haifeng ^{[1
]}

Wu, Xiping ^{[1
]}

Zheng, Wu ^{[1
,2
]}

机构：

[1] Ningbo Univ, Affiliated Lihuili Hosp, Dept Neurol, Ningbo, Zhejiang, Peoples R China

[2] Ningbo Univ, Lihuili Hosp, Neurosci Med Ctr, Ningbo Med Ctr, Ningbo, Zhejiang, Peoples R China

来源：

FRONTIERS IN PHARMACOLOGY | 2024年 / 15卷

关键词：

Parkinson's disease; alpha-Synuclein; natural products; aggregation; misfolding; CATECHOL-O-METHYLTRANSFERASE; DOSE TRANSDERMAL NICOTINE; BAICALEIN CHEWABLE TABLETS; IN-VITRO; OXIDATIVE STRESS; AMYLOID FIBRILS; EPIGALLOCATECHIN GALLATE; DOPAMINE TRANSPORTER; OLIGOMER FORMATION; NONMOTOR FEATURES;

D O I：

10.3389/fphar.2024.1468850

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Parkinson's disease (PD), as a refractory neurological disorder with complex etiology, currently lacks effective therapeutic agents. Natural products (NPs), derived from plants, animals, or microbes, have shown promising effects in PD models through their antioxidative and anti-inflammatory properties, as well as the enhancement of mitochondrial homeostasis and autophagy. The misfolding and deposition of alpha-Synuclein (alpha-Syn), due to abnormal overproduction and impaired clearance, being central to the death of dopamine (DA) neurons. Thus, inhibiting alpha-Syn misfolding and aggregation has become a critical focus in PD discovery. This review highlights NPs that can reduce alpha-Syn aggregation by preventing its overproduction and misfolding, emphasizing their potential as novel drugs or adjunctive therapies for PD treatment, thereby providing further insights for clinical translation.

引用

页数：34

共 292 条

[1] Tunneling nanotubes spread fibrillar α-synuclein by intercellular trafficking of lysosomes [J].

Abounit, Saida ;

Bousset, Luc ;

Loria, Frida ;

Zhu, Seng ;

de Chaumont, Fabrice ;

Pieri, Laura ;

Olivo-Marin, Jean-Christophe ;

Melki, Ronald ;

Zurzolo, Chiara .

EMBO JOURNAL, 2016, 35 (19) :2120-2138

[2] Curcumin Prevents Aggregation in α-Synuclein by Increasing Reconfiguration Rate [J].

Ahmad, Basir ;

Lapidus, Lisa J. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2012, 287 (12) :9193-9199

[3] Curcumin Pyrazole and its derivative (N-(3-Nitrophenylpyrazole) Curcumin inhibit aggregation, disrupt fibrils and modulate toxicity of Wild type and Mutant α-Synuclein [J].

Ahsan, Nuzhat ;

Mishra, Satyendra ;

Jain, Manish Kumar ;

Surolia, Avadhesha ;

Gupta, Sarika .

SCIENTIFIC REPORTS, 2015, 5

[4] The microbiome-gut-brain axis in Parkinson disease - from basic research to the clinic [J].

Ai Huey Tan ;

Lim, Shen Yang ;

Lang, Anthony E. .

NATURE REVIEWS NEUROLOGY, 2022, 18 (08) :476-495

[5] Recent progress in studies on the health benefits of pyrroloquinoline quinone [J].

Akagawa, Mitsugu ;

Nakano, Masahiko ;

Ikemoto, Kazuto .

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 2016, 80 (01) :13-22

[6] Multiple Protective Roles of Nanoliposome-Incorporated Baicalein against Alpha-Synuclein Aggregates [J].

Aliakbari, Farhang ;

Mohammad-Beigi, Hossein ;

Abbasi, Shahsanam ;

Rezaei-Ghaleh, Nasrollah ;

Lermyte, Frederik ;

Parsafar, Soha ;

Becker, Stefan ;

Tafreshi, Azita Parvaneh ;

O'Connor, Peter B. ;

Collingwood, Joanna F. ;

Christiansen, Gunna ;

Sutherland, Duncan S. ;

Jensen, Poul Henning ;

Morshedi, Dina ;

Otzen, Daniel E. .

ADVANCED FUNCTIONAL MATERIALS, 2021, 31 (07)

[7] Investigation of Inhibition Effect of Nicotine and Dopamine on Alpha-synuclein [J].

Alici, Hakan .

JOURNAL OF COMPUTATIONAL BIOPHYSICS AND CHEMISTRY, 2021, 20 (05) :477-494

[8] Structure and Aggregation Mechanisms in Amyloids [J].

Almeida, Zaida L. ;

Brito, Rui M. M. .

MOLECULES, 2020, 25 (05)

[9] 1,4-Naphthoquinones: Some Biological Properties and Application [J].

Aminin, Dmitry ;

Polonik, Sergey .

CHEMICAL & PHARMACEUTICAL BULLETIN, 2020, 68 (01) :46-57

[10] Bioavailability of curcumin: Problems and promises [J].

Anand, Preetha ;

Kunnumakkara, Ajaikumar B. ;

Newman, Robert A. ;

Aggarwal, Bharat B. .

MOLECULAR PHARMACEUTICS, 2007, 4 (06) :807-818

← 1 2 3 4 5 6 7 8 9 10 →