Sex-specific ultrasound imaging biomarkers of neurodegeneration in a mouse model

被引：0

作者：

Russell, Mark B. ^{[1
]}

Locke, Drew P. ^{[1
]}

Adams, Haley M. ^{[1
]}

Pelley, Alexander R. ^{[1
]}

Saghian, Rojan ^{[2
,3
]}

Maekawa, Alexandre S. ^{[1
]}

Stapleton, Darcie ^{[1
]}

Mercer, Grace V. ^{[1
]}

Sled, John G. ^{[2
,3
,4
]}

Cahill, Lindsay S. ^{[1
,5
]}

机构：

[1] Mem Univ Newfoundland, Dept Chem, St John, NF, Canada

[2] Hosp Sick Children, Mouse Imaging Ctr, Toronto, ON, Canada

[3] Hosp Sick Children, Translat Med, Toronto, ON, Canada

[4] Univ Toronto, Dept Med Biophys, Toronto, ON, Canada

[5] Mem Univ Newfoundland, Discipline Radiol, St John, NF, Canada

来源：

FRONTIERS IN AGING NEUROSCIENCE | 2025年 / 16卷

关键词：

cerebrovasculature; mouse; neurodegeneration; pulse wave velocity; sex differences; ultrasound; MILD COGNITIVE IMPAIRMENT; PULSE-WAVE VELOCITY; ARTERIAL STIFFNESS; AORTIC STIFFNESS; DEMENTIA; RISK; DISEASE; GENDER; HEALTH; WOMEN;

D O I：

10.3389/fnagi.2024.1445164

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Introduction Early detection of neurodegeneration is essential for optimizing interventions. The highly reproducible progression of neurodegeneration in the decrepit (dcr) mouse allows investigation of early biomarkers and mechanisms of brain injury.Methods Using high-frequency ultrasound, the common carotid arteries of female and male dcr and control mice were imaged longitudinally at time points bracketing the disease progression (50, 75, and 125 days of age) (n = 6 mice/group/sex).Results Over the disease time course, the female dcr mice demonstrated increased carotid artery blood flow and pulse wave velocity while the male dcr mice had a decrease in heart rate and no change in carotid artery ultrasound parameters. Early imaging biomarkers were sex-specific, with decreased carotid artery blood flow in female dcr mice and increased carotid artery diameter and decreased pulse wave velocity in males.Discussion Carotid artery and wave reflection ultrasound is a promising screening tool for early detection of neurodegeneration.

引用

页数：9

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