Dose Splitting Increases Selection for Both Target-Site and Non-Target-Site Fungicide Resistance-A Modelling Analysis

被引：0
作者：
Corkley, Isabel [1 ,2 ,3 ]
Mikaberidze, Alexey [2 ]
Paveley, Neil [4 ]
van den Bosch, Frank [5 ,6 ]
Shaw, Michael W. [2 ]
Milne, Alice E. [1 ]
机构：
[1] Net Zero & Resilient Farming, Rothamsted Res, Harpenden, England
[2] Univ Reading, Sch Agr Policy & Dev, Reading, England
[3] Agr Dev & Advisory Serv, Sustainable Agr Syst, Wolverhampton, England
[4] Agr Dev & Advisory Serv, Sustainable Agr Syst, Wolverhampton, England
[5] Univ Calif Davis, Plant Pathol Dept, Quantitat Biol & Epidemiol Grp, Davis, CA USA
[6] Agr Dev & Advisory Serv, Sustainable Agr Syst, Hereford, England
来源：
PLANT PATHOLOGY | 2025年
基金：
英国生物技术与生命科学研究理事会;
关键词：
epidemiological model; fungicide resistance management; non-target-site resistance; partial resistance; quantitative resistance; Septoria tritici blotch; SEPTORIA LEAF BLOTCH; MYCOSPHAERELLA-GRAMINICOLA; ZYMOSEPTORIA-TRITICI; WINTER-WHEAT; MANAGEMENT; DISEASE; DISSIPATION; POPULATIONS; SENSITIVITY; MECHANISMS;
D O I：
10.1111/ppa.14080
中图分类号：
S3 [农学（农艺学）];
学科分类号：
0901 ;
摘要：
Fungicide resistance management principles recommend that farmers avoid splitting the total dose applied of a fungicidal mode of action (MoA) across multiple applications per season ('dose splitting'). However, dose splitting may sometimes be needed to make another proven resistance management tactic-application in mixture with a different MoA-practically achievable, especially in cases where there are limited MoAs available for disease control. Variable effects of dose splitting on selection for resistance have been observed in field experiments, and its effect on selection for partial resistance in fungal pathogens is not well studied. An improved understanding of whether the effect of dose splitting depends on fungicide properties and the type of fungicide resistance is required. We developed a compartmental epidemiological model of Septoria leaf blotch (STB) (Zymoseptoria tritici) to investigate the effect of dose splitting on selection for both complete and partial target-site and non-target-site resistance. To solely measure the effects of dose splitting, we restricted the analysis to solo fungicide application (solo use is not recommended in practice). Our results show variable effects of dose splitting: in general, it increased the selection for both target-site and non-target-site resistance. Within the range of dose-response parameters expected for commercial fungicides, dose splitting increased the selection most for partial resistance mechanisms that result in a reduction in fungicide efficacy at low fungicide concentrations but not at high concentrations. We predict that dose splitting of a succinate dehydrogenase inhibitor (SDHI) fungicide (solo) will increase selection for target-site and non-target-site resistance by between 20% and 35%, respectively.
引用
收藏
页码：1152 / 1167
页数：16
相关论文
共 58 条
  • [1] A Guide to Fungicide Performance in Wheat, Barley and Oilseed Rape, (2024)
  • [2] Recommended Lists Disease Ratings, (2024)
  • [3] Ballu A., Deredec A., Walker A.-S., Carpentier F., Are Efficient-Dose Mixtures a Solution to Reduce Fungicide Load and Delay Evolution of Resistance? An Experimental Evolutionary Approach, Microorganisms, 9, (2021)
  • [4] Blake J.J., Gosling P., Fraaije B.A., Et al., Changes in Field Dose–Response Curves for Demethylation Inhibitor (DMI) and Quinone Outside Inhibitor (QoI) Fungicides Against Zymoseptoria tritici, Related to Laboratory Sensitivity Phenotyping and Genotyping Assays, Pest Management Science, 74, pp. 302-313, (2018)
  • [5] Boixel A.-L., Environmental Heterogeneity, a Driver of Adaptation to Temperature in Foliar Plant Pathogen Populations?, (2020)
  • [6] Comont D., Lowe C., Hull R., Et al., Evolution of Generalist Resistance to Herbicide Mixtures Reveals a Trade-Off in Resistance Management, Nature Communications, 11, (2020)
  • [7] Cools H.J., Fraaije B.A., Update on Mechanisms of Azole Resistance in Mycosphaerella graminicola and Implications for Future Control, Pest Management Science, 69, pp. 150-155, (2013)
  • [8] Corkley I., Fraaije B., Hawkins N., Fungicide Resistance Management: Maximizing the Effective Life of Plant Protection Products, Plant Pathology, 71, pp. 150-169, (2022)
  • [9] Dooley H., Shaw M.W., Mehenni-Ciz J., Spink J., Kildea S., Detection of Zymoseptoria tritici SDHI-Insensitive Field Isolates Carrying the SdhC -H152R and SdhD -R47W Substitutions, Pest Management Science, 72, pp. 2203-2207, (2016)
  • [10] Dorigan A.F., Moreira S.I., da Silva Costa Guimaraes S., Cruz-Magalhaes V., Alves E., Target and Non-Target Site Mechanisms of Fungicide Resistance and Their Implications for the Management of Crop Pathogens, Pest Management Science, 79, pp. 4731-4753, (2023)
123456