Anticancer and Antimicrobial Activity of Copper(II) Complexes with Fluorine-Functionalized Schiff Bases: A Mini-Review

被引:0
作者
Moreno-Narvaez, Maria Esther [1 ]
Gonzalez-Sebastian, Lucero [2 ]
Colorado-Peralta, Raul [3 ]
Reyes-Marquez, Viviana [4 ]
Franco-Sandoval, Luz Ofelia [5 ]
Romo-Perez, Adriana [1 ]
Cruz-Navarro, Jesus Antonio [1 ]
Manozca-Dosman, Ivone Vanessa [6 ]
Aragon-Muriel, Alberto [6 ]
Morales-Morales, David [1 ]
机构
[1] Univ Nacl Autonoma Mex, Inst Quim, Ciudad Univ,Circuito Exterior S-N, Mexico City 04510, Mexico
[2] Univ Autonoma Metropolitana, Dept Quim, Av San Rafael Atlixco 186,Leyes Reforma 1ra Secc, Mexico City 09340, Mexico
[3] Univ Veracruzana, Fac Ciencias Quim, Prolongac Oriente 6,1009 Col Rafael Alvarado, Veracruz 94340, Mexico
[4] Univ Sonora, Dept Ciencias Quim Biol, Luis Encinas & Rosales S-N, Hermosillo 83000, Sonora, Mexico
[5] Hosp Infantil Mexico Dr Federico Gomez, Lab Invest Parasitol, Calle Dr Marquez,162 Colonia Doctores, Mexico City 06720, Mexico
[6] Univ Magdalena, Grp Invest Bioquim GIB, Santa Marta 470004, Colombia
关键词
Schiff base complexes; cytotoxicity; antibacterial/antifungal activity; fluorinated complexes; copper complexes; metallodrugs; MEDICINAL CHEMISTRY;
D O I
10.3390/inorganics13020038
中图分类号
O61 [无机化学];
学科分类号
070301 ; 081704 ;
摘要
In recent years, metallodrugs have emerged as captivating and promising compounds in the fields of cancer therapy and antimicrobial agents. While noble metals have shown remarkable biological activity, increasing interest lies in utilizing more abundant and cost-effective metals in medicinal chemistry. This is primarily due to their pivotal role in biological processes and their lower cost compared to precious metals. Among these, copper(II) complexes have emerged with promising applications in medicine. Notably, copper compounds bearing Schiff bases stand out as innovative metallodrugs. They exhibit intriguing cytotoxic properties against a wide range of cancer cell lines, while also demonstrating inhibitory effects on prevalent bacterial and fungal strains. Nevertheless, research into Cu(II) complexes with Schiff bases remains of paramount interest. One strategic avenue to bolster their biological activity involves the introduction of fluorine groups into the ligands. This approach has demonstrated a significant augmentation in efficacy and selectivity, particularly in targeting cancer cells and microbial pathogens, because fluorine incorporation can improve metabolic stability and cellular uptake. This further reinforces the therapeutic potential of these metallodrugs. Thanks to these promising outcomes, research into the development of Cu(II) complexes with fluorinated Schiff bases is advancing significantly. This holds immense potential for progressing the field of medicinal chemistry, with the aim of addressing unmet clinical needs in both cancer therapy and antimicrobial treatment. This review comprehensively explores the latest advancements in Cu(II) complexes bearing fluorinated Schiff bases, encompassing diverse coordination modes. It delves into their scope and applications in cytotoxic evaluations, as well as their efficacy as antimicrobial and antifungal agents.
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页数:19
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