Extrinsic and Cell-Intrinsic Stress in the Immune Tumor Micro-Environment

被引:0
作者
Ummarino, Aldo [1 ,2 ]
Cala, Nicholas [3 ]
Allavena, Paola [2 ]
机构
[1] Humanitas Univ, Dept Biomed Sci, I-20072 Milan, Italy
[2] IRCCS Humanitas Res Hosp, I-20089 Milan, Italy
[3] Agora Biomed Sci, Etromapmacs Pole, I-71010 Foggia, Italy
关键词
metabolism; hypoxia; tumor-associated macrophages; tumor micro-environment; cancer-related inflammation; UNFOLDED PROTEIN RESPONSE; ENDOPLASMIC-RETICULUM STRESS; MACROPHAGE POLARIZATION; ALTERNATIVE ACTIVATION; MYELOID CELLS; HYPOXIA; CANCER; INHIBITION; METASTASIS; METABOLISM;
D O I
10.3390/ijms252212403
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
In continuously progressive tumor tissues, the causes of cellular stress are multiple: metabolic alterations, nutrient deprivation, chronic inflammation and hypoxia. To survive, tumor cells activate the stress response program, a highly conserved molecular reprogramming proposed to cope with challenges in a hostile environment. Not only cancer cells are affected, but stress responses in tumors also have a profound impact on their normal cellular counterparts: fibroblasts, endothelial cells and infiltrating immune cells. In recent years, there has been a growing interest in the interaction between cancer and immune cells, especially in difficult conditions of cellular stress. A growing literature indicates that knowledge of the molecular pathways activated in tumor and immune cells under stress conditions may offer new insights for possible therapeutic interventions. Counter-regulating the stress caused by the presence of a growing tumor can therefore be a weapon to limit disease progression. Here, we review the main pathways activated in cellular stress responses with a focus on immune cells present in the tumor microenvironment.
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页数:16
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