The impact of metals on cognitive impairment in the elderly and the mediating role of oxidative stress: A cross-sectional study in Shanghai, China

被引:0
|
作者
Qing, Ying [1 ,2 ]
Zheng, Jianheng [3 ]
Luo, Yingyi [2 ]
Li, Shichun [2 ]
Liu, Xiufen [2 ]
Yang, Shuyu [3 ]
Du, Jun [3 ]
Li, Yanfei [1 ]
机构
[1] Shanghai Univ Med & Hlth Sci, Affiliated Zhoupu Hosp, Shanghai 201300, Peoples R China
[2] Shanghai Univ Med & Hlth Sci, Shanghai 201318, Peoples R China
[3] Nutrilite Hlth Inst, Shanghai 201203, Peoples R China
基金
上海市自然科学基金;
关键词
Metals; Cognitive impairment; Combined exposure; Oxidative stress; Mediation effect; PLASMA AMYLOID-BETA; ALZHEIMERS-DISEASE; INDUCED NEUROTOXICITY; CHEMICAL-MIXTURES; A-BETA; CADMIUM; EXPOSURE; MEMORY; LEAD; NEURODEGENERATION;
D O I
10.1016/j.ecoenv.2024.117152
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Cognitive impairment (CI) is a prodrome of many neurodegenerative diseases with complex and unclear pathogenesis. Metal exposure has been found to be associated with CI, but existing population studies are scarce and have the limitations of single outcome and ignoring mixed exposures. This cross-sectional study was conducted in Shanghai, China, enrolling 836 seniors aged over 60 years to investigate the relationship between combined metal exposure (Lead (Pb), cadmium (Cd), and mercury (Hg)) and CI in the elderly and the mediating effect of oxidative stress. It was found that there were significant differences in urinary Pb, Cd, Hg and blood Pb levels between the CI and normal groups. Urinary Pb and Cd levels were significantly negatively correlated with Montreal Cognitive Assessment (MoCA) score, amyloid beta 42 (A beta 42), and A beta 42/40, while urinary Cd, Hg and blood Hg were significantly positively correlated with phosphorylated tau protein (P-tau). Weighted quantile sum (WQS) regression indicated that combined metal exposure had a more significant effect on CI than individual exposure. Mediation modeling revealed that plasma superoxide dismutase (SOD) was involved in the effects of urinary Cd on A beta 42/40 and P-tau, with mediation effects accounting for 20 % of the total effect. This study emphasized the combined exposure to metals, and the results can help to properly understand the association between mixed metals exposure and CI in the elderly, as well as provide population data and theoretical basis for identifying early environmental risk factors and discovering potential mechanisms of CI.
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页数:10
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