Uric Acid: A Biomarker and Pathogenic Factor of Affective Disorders and Neurodegenerative Diseases

被引：0
作者：
Chu, Teng [1 ]
Liu, Ge [1 ]
Liu, Jing [1 ]
Wu, Yue [1 ]
Fang, Weirong [1 ]
机构：
[1] China Pharmaceut Univ, Sch Basic Med Sci & Clin Pharm, State Key Lab Nat Med, Nanjing 210009, Peoples R China
来源：
CURRENT PHARMACEUTICAL DESIGN | 2025年 / 31卷 / 08期
基金：
中国国家自然科学基金;
关键词：
Uric acid; affective disorders; neurodegenerative diseases; inflammation; oxidative stress; autophagy; MAJOR DEPRESSIVE DISORDER; TERM ANTIDEPRESSANT TREATMENT; NF-KAPPA-B; OXIDATIVE STRESS; BIPOLAR DISORDER; PARKINSONS-DISEASE; COGNITIVE DYSFUNCTION; ALZHEIMERS-DISEASE; PURINE METABOLISM; MOUSE MODEL;
D O I：
10.2174/0113816128333916241003180018
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Uric acid (UA), the end-product of purine metabolism, has a complicated physiological role in the body, showing the combination of regulating inflammatory response, promoting oxidation/anti-oxidation, and modifying autophagy activity in vivo. Meanwhile, various research and theories support that inflammation, oxidative stress, and other risk factors promote the onset and progression of affective disorders and neurodegenerative diseases. Existing studies suggest that UA may be involved in the pathophysiological processes of affective disorders in various ways, and there has been a gradual advance in the understanding of the interplay between UA levels and affective disorders and neurodegenerative diseases. This review summarized the role of UA in the process of inflammation, oxidative stress, and autophagy. On this basis, we discussed the correlation between UA and affective disorders and several neurodegenerative diseases, and simultaneously analyzed the possible mechanism of its influence on affective disorders and neurodegenerative diseases, to provide a theoretical basis for UA as a biomarker or therapeutic target for the diagnosis of these diseases.
引用
收藏
页码：585 / 597
页数：13
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