Ghrelin: An Emerging Therapy for Heart Failure

被引:3
作者
Theodorakis, Nikolaos [1 ,2 ,3 ,4 ,5 ]
Feretzakis, Georgios [4 ]
Kreouzi, Magdalini [2 ,6 ]
Anagnostou, Dimitrios [1 ,2 ,7 ]
Hitas, Christos [1 ,2 ]
Verykios, Vassilios S. [4 ]
Nikolaou, Maria [1 ,2 ]
机构
[1] Sismanogleio Amalia Fleming Gen Hosp, Dept Cardiol, Melissia, Greece
[2] Sismanogleio Amalia Fleming Gen Hosp, 65 Clin, Melissia, Greece
[3] Natl & Kapodistrian Univ Athens, Sch Med, Athens, Greece
[4] Hellen Open Univ, Sch Sci & Technol, Patras, Greece
[5] NT Cardiometab, Clin Metab & Athlet Performance, Palaio Faliro, Greece
[6] Sismanogleio Amalia Fleming Gen Hosp, Dept Internal Med, Melissia, Greece
[7] Natl & Kapodistrian Univ Athens, Med Sch, Dept Hyg Epidemiol & Med Stat, Athens, Greece
关键词
anabolic agents; ghrelin; heart failure; hormone deficiency; inotropic agents; MYOCARDIAL-INFARCTION; ANGIOGENESIS; ISCHEMIA; INFUSION; CACHEXIA; RATS;
D O I
10.1111/cen.15196
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
ObjectiveGhrelin is emerging as a promising therapeutic option for heart failure (HF) due to its potent inotropic, anabolic, and cardioprotective properties. This review aims to critically examine the available clinical evidence on ghrelin therapy in HF, while also incorporating key findings from preclinical studies that support its therapeutic potential.MethodsA comprehensive search was conducted in PubMed and the Cochrane Library up to September 15, 2024, using the keywords "heart failure" and "ghrelin." From 247 identified records, four randomized controlled trials, one open-label trial, one observational study, and key preclinical studies were included. Two independent authors performed the screening and quality assessment, with any discrepancies resolved through consensus.ResultsClinical trials investigating ghrelin's acute effects in HF patients have demonstrated significant improvements in cardiac output, ranging from 15% to 30%. Moreover, one study showed that a 3-week course of ghrelin therapy significantly increased maximal oxygen consumption, lean body mass, and grip strength in HF patients. Preclinical studies further support these clinical findings, highlighting additional benefits of ghrelin, including modulation of the autonomic nervous system, promotion of vasodilation, enhancement of endothelial function, prevention of myocardial remodeling, reduction of arrhythmogenic risk, and increased muscle mass in HF models.ConclusionsGhrelin is a promising therapeutic option for HF, particularly as an inotropic agent with multifaceted benefits, including autonomic nervous system modulation, anabolic effects, and metabolic regulation. However, further trials are required to confirm its long-term efficacy and safety and assess whether its benefits can translate into reductions in hard clinical endpoints.
引用
收藏
页码:403 / 412
页数:10
相关论文
共 45 条
  • [1] Testosterone replacement therapy in hypogonadal male patients with hypogonadism and heart failure: a meta-analysis of randomized controlled studies
    Cannarella, Rossella
    Barbagallo, Federica
    Crafa, Andrea
    Mongioi, Laura M.
    Aversa, Antonio
    Greco, Emanuela
    Condorelli, Rosita A.
    La Vignera, Sandro
    Calogero, Aldo E.
    [J]. MINERVA UROLOGY AND NEPHROLOGY, 2022, 74 (04): : 418 - 427
  • [2] Multiple hormonal and metabolic deficiency syndrome predicts outcome in heart failure: the TOSCA. Registry
    Cittadini, Antonio
    Salzano, Andrea
    Iacoviello, Massimo
    Triggiani, Vincenzo
    Rengo, Giuseppe
    Cacciatore, Francesco
    Maiello, Ciro
    Limongelli, Giuseppe
    Masarone, Daniele
    Perticone, Francesco
    Cimellaro, Antonio
    Filardi, Pasquale Perrone
    Paolillo, Stefania
    Mancini, Antonio
    Volterrani, Maurizio
    Vriz, Olga
    Castello, Roberto
    Passantino, Andrea
    Campo, Michela
    Modesti, Pietro A.
    De Giorgi, Alfredo
    Monte, Ines P.
    Puzzo, Alfonso
    Ballotta, Andrea
    D'Assante, Roberta
    Arcopinto, Michele
    Gargiulo, Paola
    Sciacqua, Angela
    Bruzzese, Dario
    Colao, Annamaria
    Napoli, Raffaele
    Suzuki, Toru
    Eagle, Kim A.
    Ventura, Hector O.
    Marra, Alberto M.
    Bossone, Eduardo
    [J]. EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY, 2021, 28 (15) : 1691 - 1700
  • [3] The GH-IGF-I axis and the cardiovascular system: clinical implications
    Colao, Annamaria
    [J]. CLINICAL ENDOCRINOLOGY, 2008, 69 (03) : 347 - 358
  • [4] Subacute ghrelin administration inhibits apoptosis and improves ultrastructural abnormalities in remote myocardium post-myocardial infarction
    Eid, Refaat A.
    Zaki, Mohamed Samir Ahmed
    Al-Shraim, Mubarak
    Eleawa, Samy M.
    El-kott, Attalla Farag
    Al-Hashem, Fahaid H.
    Eldeen, Muhammad Alaa
    Ibrahim, Hoja
    Aldera, Hussain
    Alkhateeb, Mahmoud A.
    [J]. BIOMEDICINE & PHARMACOTHERAPY, 2018, 101 : 920 - 928
  • [5] Acyl ghrelin increases cardiac output while preserving right ventricular-pulmonary arterial coupling in heart failure
    Erhardsson, Mikael
    Faxen, Ulrika L.
    Venkateshvaran, Ashwin
    Hage, Camilla
    Pironti, Gianluigi
    Thorvaldsen, Tonje
    Webb, Dominic-Luc
    Hellstroem, Per M.
    Andersson, Daniel C.
    Stahlberg, Marcus
    Lund, Lars H.
    [J]. ESC HEART FAILURE, 2024, 11 (01): : 601 - 605
  • [6] Ghrelin: more than a natural GH secretagogue and/or an orexigenic factor
    Ghigo, E
    Broglio, F
    Arvat, E
    Maccario, M
    Papotti, M
    Muccioli, G
    [J]. CLINICAL ENDOCRINOLOGY, 2005, 62 (01) : 1 - 17
  • [7] Neurohormonal activation in heart failure with reduced ejection fraction
    Hartupee, Justin
    Mann, Douglas L.
    [J]. NATURE REVIEWS CARDIOLOGY, 2017, 14 (01) : 30 - 38
  • [8] Endogenous production of ghrelin and beneficial effects of its exogenous administration in monocrotaline-induced pulmonary hypertension
    Henriques-Coelho, T
    Correia-Pinto, J
    Roncon-Albuquerque, R
    Baptista, MJ
    Lourenço, AP
    Oliveira, LM
    Brandao-Nogueira, A
    Teles, A
    Fortunato, JM
    Leite-Moreira, AF
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2004, 287 (06): : H2885 - H2890
  • [9] Ghrelin inhibits post-infarct myocardial remodeling and improves cardiac function through anti-inflammation effect
    Huang, Cong-Xin
    Yuan, Ming-Jie
    Huang, He
    Wu, Gang
    Liu, Yu
    Yu, Sheng-Bo
    Li, Hai-Tao
    Wang, Tao
    [J]. PEPTIDES, 2009, 30 (12) : 2286 - 2291
  • [10] Effect of Ghrelin on Mortality and Cardiovascular Outcomes in Experimental Rat and Mice Models of Heart Failure: A Systematic Review and Meta-Analysis
    Khatib, Mahalaqua Nazli
    Shankar, Anuraj
    Kirubakaran, Richard
    Agho, Kingsley
    Simkhada, Padam
    Gaidhane, Shilpa
    Saxena, Deepak
    Unnikrishnan, B.
    Gode, Dilip
    Gaidhane, Abhay
    Quazi Syed, Zahiruddin
    [J]. PLOS ONE, 2015, 10 (05):