Dysplasia and Colorectal Cancer Surveillance in Ulcerative Colitis Patients in Latin America: Real-World Data

被引:0
作者
Parra-Izquierdo, Viviana [1 ,2 ]
Otero-Regino, William [3 ,4 ,5 ]
Juliao-Banos, Fabian [6 ]
Frias-Ordonez, Juan Sebastian [3 ,4 ]
Ibanez-Pinilla, Edgar [7 ]
Gil-Parada, Fabio Leonel [8 ]
Marulanda-Fernandez, Hernando [3 ,4 ,5 ,9 ]
Otero-Parra, Lina [3 ,5 ]
Otero-Ramos, Elder [5 ,9 ]
Puentes-Manosalva, Fabian Eduardo [10 ]
Rojas, Gerardo Andres Guzman [11 ,12 ]
Ernest-Suarez, Kenneth [13 ,14 ]
Villa-Ovalles, Keyla [15 ]
Paredes-Mendez, Juan Eloy [16 ,17 ]
Jara-Alba, Maria Luisa [18 ]
Andrade-Zamora, David [19 ]
Ardila-Baez, Manuel Alonso [20 ]
Florez-Sarmiento, Cristian [2 ,21 ]
Veitia, Guillermo [22 ,23 ]
Sanchez, Abel [24 ]
Arango-Molano, Lazaro Antonio
Fluxa, Fernando [25 ]
Queiroz, Natalia Sousa Freitas [26 ]
Serrano, Mariastella [27 ]
机构
[1] Int Hosp Colombia, Gastroenterol & Rheumatol, Bucaramanga, Colombia
[2] Univ El Bosque, Cellular & Mol Immunol Grp INMUBO, Bogota, Colombia
[3] Univ Nacl Colombia, Gastroenterol, Bogota, Colombia
[4] Natl Univ Hosp Colombia, Gastroenterol & Digest Endoscopy, Bogota, Colombia
[5] Gastroenterol & Endoscopy Ctr, Gastroenterol & Digest Endoscopy, Bogota, Colombia
[6] Pablo Tobon Uribe Hosp, Gastroenterol, Medellin, Colombia
[7] El Bosque Univ, Fac Med, Bogota, Colombia
[8] Colombia Clin, Bogota, Colombia
[9] Cent Police Hosp, Bogota, Colombia
[10] Univ Caldas, Gastroenterol, Union Surg, ODO,Zentria Salud, Manizales, Caldas, Colombia
[11] Farallones Clin, Gastroenterol, Cali, Valle Del Cauca, Colombia
[12] Colsanitas Chipi Chape Med Ctr Cali, Gastroenterol, Valle Del Cauca, Colombia
[13] Univ Costa Rica, Sch Med, San Jose, Costa Rica
[14] Hosp Mexico, Inflammatory Bowel Dis Unit, Caja Costarricense Seguro Social, San Jose, Costa Rica
[15] Hosp Luis E Aybar, Gastroenterol & Digest Endoscopy, Santo Domingo, Dominican Rep
[16] Guillermo Almenara Natl Hosp, Gastroenterol, Lima, Peru
[17] Int Clin, Gastroenterol, Lima, Peru
[18] Teodoro Maldonado Carbo Specialty Hosp, Gastroenterol, Guayaquil, Ecuador
[19] Hosp Ecuadorian Inst Social Secur Cuenca, Gastroenterol, Cuenca, Ecuador
[20] Univ La Sabana, Gastroenterol, Chia, Colombia
[21] Hosp Int Colombia, Gastroenterol, Bucaramanga, Colombia
[22] Hosp Vargas Caracas, Gastroenterol, Caracas, Venezuela
[23] Univ Cent Venezuela, Gastroenterol, Caracas, Venezuela
[24] Roosevelt Hosp, Gastroenterol & Digest Endoscopy, Guatemala City, Guatemala
[25] Clin Meds, Gastroenterol, Santiago, Chile
[26] Pontificia Univ Catolica Parana PUCPR, Hlth Sci Grad Program, Curitiba, Brazil
[27] Georgetown Univ, Dept Pediat, Washington, DC USA
关键词
inflammatory bowel diseases; colonoscopy; colonic neoplasms; prognosis; colitis; ulcerative; INFLAMMATORY-BOWEL-DISEASE; CROHNS-DISEASE; CHROMOENDOSCOPY; COLONOSCOPY; NEOPLASIA; EXPERIENCE; RISK; GASTROENTEROLOGY; MANAGEMENT; DIAGNOSIS;
D O I
10.1093/crocol/otae081
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Background: The prevalence of colorectal cancer (CRC) in patients with ulcerative colitis (UC) is higher than in the general population, in Latin America there is a progressive increase of UC, and information about CRC screening in inflammatory bowel disease (IBD) is scarce. The aim of this study was to analyze the findings of endoscopic surveillance of CRC in patients with IBD according to available technology. Methods: Multicenter, cross-sectional, analytical study conducted in Latin American countries, in patients with UC, predominantly with more than 8 years of diagnosis and different degrees of disease activity. Surveillance colonoscopies were performed according to available technology. Risk factors for dysplasia detection were analyzed. Results: One hundred and forty-four patients, 55.5% women, mean age 47.3 (range 17.1 to 90; SD 15.64) years and mean duration of disease 12.71 (range 0.64 to 57.13; SD 8.08) years. Forty-nine lesions were identified, 18 corresponded to dysplasia. The detection rate of dysplasia per lesion and per procedure was 36.7% and 12.5%, respectively. By logistic regression analysis, the duration of disease (OR 1.12;95%CI:1.047 to 1.215, P = .002) and the presence of post-inflammatory polyps (OR 3.4;95%CI:1.11 to 10.36, P = .031) were risk factors for higher detection of dysplasia. Digital chromoendoscopy was associated with greater detection of dysplasia (OR 4.99, 95%CI: 1.092 to 22.864, P = .038). Conclusions: In our region, the duration of disease and the presence of post-inflammatory polyps were the factors with the highest association for dysplasia detection, and digital chromoendoscopy with directed biopsies was the technique of choice. The implementation of a specific surveillance program in colonoscopy in IBD is an effective strategy to achieve high detection rates.
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共 53 条
[1]   Primary sclerosing cholangitis [J].
Angulo, P ;
Lindor, KD .
HEPATOLOGY, 1999, 30 (01) :325-332
[2]  
[Anonymous], 2003, GASTROINTEST ENDOSC, V58, pS3
[3]   Chromoendoscopy versus narrow band imaging in UC: a prospective randomised controlled trial [J].
Bisschops, Raf ;
Bessissow, Talat ;
Joseph, Joseph A. ;
Baert, Filip ;
Ferrante, Marc ;
Ballet, Vera ;
Willekens, Hilde ;
Demedts, Ingrid ;
Geboes, Karel ;
De Hertogh, Gert ;
Vermeire, Severine ;
Rutgeerts, Paul ;
Van Assche, Gert .
GUT, 2018, 67 (06) :1087-1094
[4]  
Bossard C, 2007, ONCOL REP, V18, P1093
[5]   Comparative Acceptability and Perceived Clinical Utility of Monitoring Tools: A Nationwide Survey of Patients with Inflammatory Bowel Disease [J].
Buisson, Anthony ;
Gonzalez, Florent ;
Poullenot, Florian ;
Nancey, Stephane ;
Sollellis, Elisa ;
Fumery, Mathurin ;
Pariente, Benjamin ;
Flamant, Mathurin ;
Trang-Poisson, Caroline ;
Bonnaud, Guillaume ;
Mathieu, Stephane ;
Thevenin, Alain ;
Duruy, Marc ;
Filippi, Jerome ;
L'hopital, Francois ;
Luneau, Fabrice ;
Michalet, Veronique ;
Genes, Julien ;
Achim, Anca ;
Cruzille, Emmanuelle ;
Bommelaer, Gilles ;
Laharie, David ;
Peyrin-Biroulet, Laurent ;
Pereira, Bruno ;
Nachury, Maria ;
Bouguen, Guillaume .
INFLAMMATORY BOWEL DISEASES, 2017, 23 (08) :425-433
[6]   Strategies for Detecting Colorectal Cancer in Patients with Inflammatory Bowel Disease: A Cochrane Systematic Review and Meta-Analysis [J].
Bye, William A. ;
Ma, Christopher ;
Nguyen, Tran M. ;
Parker, Claire E. ;
Jairath, Vipul ;
East, James E. .
AMERICAN JOURNAL OF GASTROENTEROLOGY, 2018, 113 (12) :1801-1809
[7]   Real-life chromoendoscopy for neoplasia detection and characterisation in long-standing IBD [J].
Carballal, Sabela ;
Maisterra, Sandra ;
Lopez-Serrano, Antonio ;
Gimeno-Garcia, Antonio Z. ;
Isabel Vera, Maria ;
Carlos Marin-Garbriel, Jose ;
Diaz-Tasende, Jose ;
Marquez, Lucia ;
Antonio Alvarez, Marco ;
Hernandez, Luis ;
De Castro, Luisa ;
Gordillo, Jordi ;
Puig, Ignasi ;
Vega, Pablo ;
Bustamante-Balen, Marco ;
Acevedo, Juan ;
Penas, Beatriz ;
Lopez-Ceron, Maria ;
Ricart, Elena ;
Cuatrecasas, Miriam ;
Jimeno, Mireya ;
Pellise, Maria .
GUT, 2018, 67 (01) :70-78
[8]  
Christensen KR, 2019, GASTROENTEROLOGY, V156, pS943
[9]   No Increased Risk of Colorectal Neoplasia in Patients With Inflammatory Bowel Disease and Postinflammatory Polyps [J].
de Jong, Michiel E. ;
Gillis, Veerle E. L. M. ;
Derikx, Lauranne A. A. P. ;
Hoentjen, Frank .
INFLAMMATORY BOWEL DISEASES, 2020, 26 (09) :1383-1389
[10]   Performance measures for colonoscopy in inflammatory bowel disease patients: European Society of Gastrointestinal Endoscopy (ESGE) Quality Improvement Initiative [J].
Dekker, Evelien ;
Nass, Karlijn J. ;
Iacucci, Marietta ;
Murino, Alberto ;
Sabino, Joao ;
Bugajski, Marek ;
Carretero, Cristina ;
Cortas, George ;
Despott, Edward J. ;
East, James E. ;
Kaminski, Michal F. ;
Karstensen, John Gasdal ;
Keuchel, Martin ;
Lowenberg, Mark ;
Monged, Ashraf ;
Nardone, Olga M. ;
Neumann, Helmut ;
Omar, Mahmoud M. ;
Pellise, Maria ;
Peyrin-Biroulet, Laurent ;
Rutter, Matthew D. ;
Bisschops, Raf .
ENDOSCOPY, 2022, 54 (09) :904-915