Exploring the Role of Extrachromosomal Circular DNA in Human Diseases

被引：1
作者：
Peng, Yali [1 ]
Tao, Huihui [1 ,2 ,3 ]
Wang, Guoying [1 ]
Wu, Mengyao [1 ]
Xu, Tinatin [1 ]
Wen, Chunmei [1 ]
Zheng, Xuejia [4 ]
Dai, Yong [1 ,2 ,3 ,4 ]
机构：
[1] Anhui Univ Sci & Technol, Sch Med, Huainan, Peoples R China
[2] Key Lab Ind Dust Deep Reduct & Occupat Hlth & Safe, Huainan, Peoples R China
[3] Anhui Prov Engn Lab Occupat Hlth & Safety, Huainan, Peoples R China
[4] Anhui Univ Sci & Technol, Hosp 1, Huainan, Peoples R China
来源：
CYTOGENETIC AND GENOME RESEARCH | 2025年 / 164卷 / 5-6期
关键词：
Extrachromosomal circular DNA; Autoimmune disease; Tumor; Hereditary disease; Biomarker; Mechanism of action; HOMOGENEOUSLY STAINING REGIONS; DOUBLE MINUTE CHROMOSOMES; MITOCHONDRIAL-DNA; MURINE MODEL; SOLID TUMORS; IN-VIVO; AMPLIFICATION; CELLS; GENE; IDENTIFICATION;
D O I：
10.1159/000541563
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Background: Extrachromosomal circular DNA (eccDNA) has emerged as a central focus in molecular biology, with various types being found across species through advanced techniques, including high-throughput sequencing. This dynamic molecule exerts a significant influence on aging and immune function and plays pivotal roles in autoimmune diseases, type 2 diabetes mellitus, cancer, and genetic disorders. Summary: This comprehensive review investigates the classification, characteristics, formation processes, and multifaceted functions of eccDNA, providing an in-depth exploration of its mechanisms in diverse diseases. Key Messages: The goal of this review was to establish a robust theoretical foundation for a more comprehensive understanding of eccDNA, offering valuable insights for the development of clinical diagnostics and innovative therapeutic strategies in the context of related diseases. © 2024 S. Karger AG, Basel.
引用
收藏
页码：181 / 193
页数：13
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