Exploring the Role of Extrachromosomal Circular DNA in Human Diseases

被引：1

作者：

Peng, Yali ^{[1
]}

Tao, Huihui ^{[1
,2
,3
]}

Wang, Guoying ^{[1
]}

Wu, Mengyao ^{[1
]}

Xu, Tinatin ^{[1
]}

Wen, Chunmei ^{[1
]}

Zheng, Xuejia ^{[4
]}

Dai, Yong ^{[1
,2
,3
,4
]}

机构：

[1] Anhui Univ Sci & Technol, Sch Med, Huainan, Peoples R China

[2] Key Lab Ind Dust Deep Reduct & Occupat Hlth & Safe, Huainan, Peoples R China

[3] Anhui Prov Engn Lab Occupat Hlth & Safety, Huainan, Peoples R China

[4] Anhui Univ Sci & Technol, Hosp 1, Huainan, Peoples R China

来源：

CYTOGENETIC AND GENOME RESEARCH | 2025年 / 164卷 / 5-6期

关键词：

Extrachromosomal circular DNA; Autoimmune disease; Tumor; Hereditary disease; Biomarker; Mechanism of action; HOMOGENEOUSLY STAINING REGIONS; DOUBLE MINUTE CHROMOSOMES; MITOCHONDRIAL-DNA; MURINE MODEL; SOLID TUMORS; IN-VIVO; AMPLIFICATION; CELLS; GENE; IDENTIFICATION;

D O I：

10.1159/000541563

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Background: Extrachromosomal circular DNA (eccDNA) has emerged as a central focus in molecular biology, with various types being found across species through advanced techniques, including high-throughput sequencing. This dynamic molecule exerts a significant influence on aging and immune function and plays pivotal roles in autoimmune diseases, type 2 diabetes mellitus, cancer, and genetic disorders. Summary: This comprehensive review investigates the classification, characteristics, formation processes, and multifaceted functions of eccDNA, providing an in-depth exploration of its mechanisms in diverse diseases. Key Messages: The goal of this review was to establish a robust theoretical foundation for a more comprehensive understanding of eccDNA, offering valuable insights for the development of clinical diagnostics and innovative therapeutic strategies in the context of related diseases. © 2024 S. Karger AG, Basel.

引用

页码：181 / 193

页数：13

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