METTL5 Promotes Tumor Progression in Oral Squamous Cell Carcinoma by Activating the Myc Pathway

被引:0
|
作者
Huang, Rong [1 ]
Feng, Xingyu [2 ]
Zhou, Tao [1 ]
Lu, Jiajing [1 ]
Wang, Ying [1 ]
Zhang, Shuangyue [2 ]
Zhang, Wei [2 ]
机构
[1] Taizhou Polytech Coll, Sch Med, Taizhou, Jiangsu, Peoples R China
[2] Nanjing Med Univ, Affiliated Huaian Peoples Hosp 1, Huaian, Jiangsu, Peoples R China
关键词
biomarker; METTL5; OSCC; prognosis; the Myc pathway; METABOLISM; M(6)A;
D O I
10.1111/jop.13601
中图分类号
R78 [口腔科学];
学科分类号
1003 ;
摘要
BackgroundIt has been observed that methyltransferases-like 5 (METTL5) is a key mediator underlying tumorigenesis in humans. This study aimed to investigate the biological function, expression pattern, and clinical significance of METTL5 in oral squamous cell carcinoma (OSCC).MethodsBioinformatics interrogations and immunohistochemical staining were utilized for determining the expression and localization of METTL5 in OSCC, and revealing the relationship between the expression of METTL5 and prognosis. Cell phenotype experiments and xenograft models were used to detect the impact of METTL5 silencing on OSCC. Gene Set Enrichment Analysis, Spearman correlation, and c-Myc overexpression plasmid was utilized for exploring the regulatory effects of METTL5 on the Myc pathway.ResultsMETTL5 was overexpressed in OSCC and correlated with reduced survival. Cell proliferation, migration, and invasion were significantly inhibited by METTL5 knockdown in vitro, and tumor growth was impaired in vivo. Moreover, METTL5 was capable of activating the Myc pathway. The influences of knockdown of METTL5 on Cal27 cell biological behaviors were reversed by overexpression of c-Myc.ConclusionsOur data suggested that METTL5 may act as a putative oncogene and prognostic biomarker in OSCC. The Myc pathway appears to be involved in cell proliferation, migration, invasion, and apoptosis in OSCC mediated by METTL5.
引用
收藏
页码:91 / 99
页数:9
相关论文
共 50 条
  • [31] CircRNA_002178 promotes the proliferation and migration of oral squamous cell carcinoma cells by activating the Akt/mTOR pathway
    Yang, Y.
    Ci, H-S
    Mao, Y-L
    Li, J-W
    Zuo, J-H
    EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, 2020, 24 (11) : 6122 - 6130
  • [32] Integrin α5 promotes tumor progression and is an independent unfavorable prognostic factor in esophageal squamous cell carcinoma
    Xie, Jian-Jun
    Guo, Jin-Cheng
    Wu, Zhi-Yong
    Xu, Xiu-E
    Wu, Jian-Yi
    Chen, Bo
    Ran, Li-Qiang
    Liao, Lian-Di
    Li, En-Min
    Xu, Li-Yan
    HUMAN PATHOLOGY, 2016, 48 : 69 - 75
  • [33] Porphyromonas gingivalis Promotes Oral Squamous Cell Carcinoma Progression by Modulating Autophagy
    Yuan, Keyong
    Xu, Shengming
    Liu, Guanglong
    Han, Yong
    Hu, Jingzhou
    Zhang, Wuchang
    Zhang, Zhiyuan
    Liu, Liu
    Huang, Zhengwei
    Zhu, Yu
    Liu, Shuli
    ORAL DISEASES, 2024,
  • [34] Porphyromonas gingivalis Promotes Oral Squamous Cell Carcinoma Progression in an Immune Microenvironment
    Wen, L.
    Mu, W.
    Lu, H.
    Wang, X.
    Fang, J.
    Jia, Y.
    Li, Q.
    Wang, D.
    Wen, S.
    Guo, J.
    Dai, W.
    Ren, X.
    Cui, J.
    Zeng, G.
    Gao, J.
    Wang, Z.
    Cheng, B.
    JOURNAL OF DENTAL RESEARCH, 2020, 99 (06) : 666 - 675
  • [35] Circ_LPAR3 promotes the progression of oral squamous cell carcinoma
    Li, Li
    Yin, Ye
    Nan, Fanglong
    Ma, Zeyu
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2022, 589 : 215 - 222
  • [36] The human 18S rRNA m6A methyltransferase METTL5 promotes tumorigenesis via DEPDC1 in lung squamous cell carcinoma
    Yan, Yang
    Fu, Jianjun
    FRONTIERS IN ONCOLOGY, 2025, 15
  • [37] Abnormal downregulation of 10-formyltetrahydrofolate dehydrogenase promotes the progression of oral squamous cell carcinoma by activating PI3K/Akt/Rb pathway
    Qu, Yi
    He, Ying
    Ruan, Hanjin
    Qin, Lizheng
    Han, Zhengxue
    CANCER MEDICINE, 2023, 12 (05): : 5781 - 5797
  • [38] METTL3 Facilitates Tumor Progression by COL12A1/MAPK Signaling Pathway in Esophageal Squamous Cell Carcinoma
    Li, Jiali
    Li, Zhenhua
    Xu, Yanzhao
    Huang, Chao
    Shan, Baoen
    JOURNAL OF CANCER, 2022, 13 (06): : 1972 - 1984
  • [39] METTL14 Promotes Oral Squamous Cell Carcinoma Progression by Regulating the mRNA and m6A Levels of CALD1
    Chen, Ruixue
    Zhang, Suxin
    Li, Hexiang
    Yang, Mengyuan
    Lu, Yiwen
    Zhang, Xudong
    JOURNAL OF ENVIRONMENTAL PATHOLOGY TOXICOLOGY AND ONCOLOGY, 2023, 42 (03) : 71 - 81
  • [40] The microRNA-10b-Bim axis promotes cancer progression through activating autophagy in oral squamous cell carcinoma
    Shaoming Li
    Ling Gao
    Jiacheng Liu
    Chao Guo
    Jingjing Zheng
    Keqian Zhi
    Wenhao Ren
    Cell Death Discovery, 8